Stem Cell Therapy Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028, Segmented By Type (Allogenic Transplants, Autologous Transplants), By Cell Source (Adipose Tissue-Derived Mesenchymal Stem Cells, Bone Marrow-Derived Mesenchymal Stem Cells, Cord Blood/Embryonic Stem Cells), By Application (Cancer, Musculoskeletal Disorder, Wounds and Injuries, Cardiovascular Disease, Others), By End User (Hospitals and Surgical Centers, Therapeutic Companies), By Region and Competition

  • Industry : Healthcare
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  • Published Date : NA
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Summary

Report Description

Forecast Period

2024-2028

Market Size (2022)

USD 261.07 Million

CAGR (2023-2028)

12.39%

Fastest Growing Segment

Allogenic Transplants

Largest Market

North America

Market Overview

Global Stem Cell Therapy Market has valued at USD 261.07 Million in 2022 and is anticipated to project impressive growth in the forecast period with a CAGR of 12.39% through 2028. Stem cell therapy, also referred to as regenerative medicine, facilitates the repair response of diseased, dysfunctional, or injured tissue through the utilization of stem cells or their derivatives. It represents the subsequent phase in organ transplantation, substituting donor organs—which are limited in availability—with cells. Stem cells possess the capability to differentiate into various cell types within the human body, functioning as a restorative mechanism. There exist two primary classifications of stem cells: embryonic stem cells and adult stem cells. Stem cells are further categorized into two major groups: pluripotent and multipotent. Pluripotent stem cells, derived from embryos or fetal tissues, undergo replication and contribute to the development of cells and tissues within the mesoderm, ectoderm, and endoderm—the three primary germ layers.

Key Market Drivers

Increasing Technological Advancement in Stem Cell Therapeutics

The progress of stem cell therapies has been facilitated by advancements in stem cell isolation, expansion, and differentiation techniques. Scientists are currently investigating different sources of stem cells, such as embryonic stem cells, induced pluripotent stem cells (iPSCs), and adult stem cells. Furthermore, emerging technologies like gene editing (e.g., CRISPR) hold promise for improving the precision and effectiveness of stem cell-based treatments. The constant awareness and availability of stem cell therapies have triggered an increasing demand for innovation and system development. Market players are actively seeking collaborations to enhance their research and development activities, aiming to expand the stem cell treatment market in both developing and developed nations. Substantial funding has been invested in cell-based research, particularly in the field of induced pluripotent stem cells. This technique involves genetic reprogramming of adult human stem cells to obtain embryonic-like stem cells, serving as a viable alternative in the market.

Surging Demand for Stem Cell Therapy

Stem cell therapy has garnered considerable attention and acceptance owing to its potential in regenerative medicine. It offers promise in the treatment of various conditions, including neurological disorders, cardiovascular diseases, orthopedic injuries, and autoimmune disorders. There has been a consistent growth in stem cell research, leading to an increase in approvals from regulatory authorities. Consequently, the market for stem cell therapy has experienced significant growth in the past and is expected to continue growing during the forecast period. Ongoing research and development activities in the field have also spurred demand for gene and cell treatments utilizing stem cells. Furthermore, the rising number of registered clinical trials is likely to have a considerable impact on market demand and drive sales growth.

Increasing in Government Support for Research and Development Activities

In developed nations and other countries with strong purchasing power, the demand for innovative medicines is expected to experience significant growth in the coming years. These medicines hold promise for the treatment of various disorders, including cardiovascular, neurological, and autoimmune conditions. The market for stem cell treatment or therapy is projected to expand due to the increasing prevalence of these diseases worldwide. The market has also witnessed growth in the past, fueled by heightened funding. While using embryos in treatment raises ethical concerns, it is important to acknowledge their potential in saving lives. Continuous and development efforts have yielded innovative therapies. iPSCs are widely utilized by researchers worldwide to conduct studies on cancer. This product has been employed in clinical trials targeting diseases such as Parkinson's and Alzheimer's, leading to a projected market growth in the coming years. During the pandemic, researchers focused on developing treatments for combating the COVID-19 virus, with the use of stem cells showing promise. To enhance research activities in the stem cell market, the Australian government has made significant investments and provided a comprehensive roadmap for the next decade.

Rising Chronic Disorders

Chronic diseases are prevalent health issues globally, affecting one out of every three adults worldwide. These conditions encompass a range of ailments including cancer, musculoskeletal and neurologic disorders, chronic injuries, and cardiovascular and gastrointestinal diseases. They often necessitate hospitalization, long-term disability, diminished quality of life, and can even be fatal.

Stem cells have been utilized in various clinical trials for treating the virus, offering improved treatment options and significantly reducing the number of cases. Furthermore, the use of regenerative medicines may play a vital role in decreasing the infection rate among individuals. Anticipated growth in demand for this product is expected in the upcoming years, driven by an increase in clinical trials and obtaining necessary approvals from regulatory authorities. With a rising prevalence of chronic diseases worldwide, the demand for stem cell therapy is projected to expand, presenting favorable market opportunities in the future.


Key Market Challenges

High-Cost Treatment

Developing and implementing stem cell therapies involves significant research, clinical trials, and manufacturing costs. The high costs associated with research, development, and production can limit accessibility for patients. The expansion of the cell treatment market has been hindered by its high cost. As individuals seek out the latest therapeutic options, cell treatments have gained popularity as a treatment choice. Despite the significant increase in demand, cell treatments remain prohibitively expensive. Joint injections alone can cost up to $1,000, while more complex procedures may reach up to $100,000. In the United States, the average cost of stem cell therapy is projected to range between $4,000 and $8,000 per patient in 2020. Consequently, the growth of the stem cell therapy market is constrained by the elevated cost of treatment.

Competition with Established Therapies

Stem cell therapies may need to demonstrate superiority over existing treatments to gain acceptance from medical professionals, insurers, and regulatory bodies. Stem cell therapies are often considered as potential alternatives or complements to established therapies in various medical fields. While stem cells hold great promise, they also face competition and comparisons with well-established treatment approaches. Stem cell therapies require rigorous testing and regulatory approval to ensure patient safety. The unpredictable behavior of stem cells and concerns about potential side effects, such as tumor formation or immune responses, pose challenges that must be addressed before widespread adoption.

Key Market Trends

Increased Clinical Trials and Research

The field of stem cell therapy is likely to see continued growth in clinical trials and research studies. As scientists better understand stem cell behavior and optimize their use, more evidence will be generated to support their efficacy and safety for various medical conditions.  Ongoing research will likely reveal new and diverse applications for stem cell therapy across various medical conditions. As the understanding of stem cells expands, scientists may identify previously unrecognized opportunities for treatment.

International Collaboration

Collaboration among researchers and institutions on a global scale could accelerate progress in stem cell research. Shared knowledge and resources could lead to faster advancements and breakthroughs. Advances in stem cell research could lead to more precise and personalized therapies. By tailoring treatments to individual patients based on their specific needs and genetic makeup, researchers can enhance therapeutic outcomes and minimize potential risks. Successful outcomes from clinical trials could attract investment and lead to the commercial development of stem cell therapies. This could make these treatments more widely available to patients.

Segmental Insights

Type Insights

The allogenic stem cell therapy segment achieved the highest market revenue in 2021 by establishing a new immune system for patients through engraftment of donor cells. This therapeutic approach offers potential treatment for various malignant and non-cancerous disorders including acute leukemia, chronic leukemia, Hodgkin's lymphoma, adrenoleukodystrophy, bone marrow failure syndromes, and more.

The rising number of cancer patients has stimulated the demand for Omidubicel, an advanced cell therapy specifically designed for individuals with blood cancer. Notably, in 2022, the Managing Director of Duke Cancer Institute acknowledged the efficacy of allogenic stem cell transplant using the novel cell therapy Omidubicel in a phase 3 trial (NCT02730299), surpassing the standard myeloablative umbilical cord blood treatment.

The growth of this segment can be attributed to factors such as cost-effectiveness and the expansion of stem cell banking. Additionally, numerous cell therapy companies are redirecting their focus towards the development of allogenic cell therapy products, which is expected to further propel the expansion of this segment.

Cell Source Insights

The adipose tissue-derived mesenchymal stem cells segment emerged as the primary revenue contributor in 2022 and is expected to maintain its dominance throughout the forecast period in the stem cell therapy market. This can be attributed to the growing number of cancer patients, as well as the expanding target population, increased exposure to harmful radiation, and government initiatives. Conversely, the bone marrow-derived mesenchymal stem cells segment is projected to exhibit the highest market growth during the forecast period, driven by a higher incidence of chronic and fatal diseases like musculoskeletal disorders, and the rise in tobacco smoking, including passive smoking, which is associated with cancer.


Regional Insights

Based on regional analysis, North America accounted for the largest share in the stem cell therapy market in 2022. The dominance of the North America region can be attributed to the presence of major market players in the region, advanced healthcare infrastructure, promising reimbursement and government policies, as well as increasing awareness about stem cell therapies among the population. These factors contribute to the growth of the stem cells therapy market in this region. Moreover, investors are highly attracted to the stem cells therapy market in North America due to the rising research and development activities aimed at developing advanced therapies and providing better solutions to healthcare professionals and patients with critical disorders.

The Asia Pacific region is expected to be the next largest growing market, driven by the presence of emerging pharmaceutical companies collaborating in countries such as China, Japan, and India to invest in this market. The region also witnesses the entry of small start-ups in the stem cell therapy market. Ongoing large-scale clinical trials and the presence of stem cell banks in the region are expected to further expand the market's global footprint. Europe is anticipated to be the next largest region in the market.

Recent Developments

In April 2022, Aspen Neuroscience, Inc. initiated the first patient screening study of its kind, collaborating with multiple clinical screening sites across the United States. The company's Trial-Ready Cohort Study serves as a preliminary step towards submitting an Investigational New Drug (IND) application to the United States Food & Drug Administration. The application aims to investigate the potential of iPSC-derived cell replacement therapies for Parkinson's disease.

In April 2022, TreeFrog Therapeutics launched The Stem Cell SpaceShot Grant, providing USD 100,000 in research funding for advancements in the field of stem cell biology and regenerative medicine.

In February 2021, American CryoStem entered into a collaboration with BioTherapeutic Labs Corp to facilitate research and development in the field of stem cells. The primary objective of this collaboration was to enhance and refine protocols utilizing CRYO's ATCell and BTL's human umbilical cord-based product lines.

In June 2020, Baylx Inc. obtained U.S. FDA clearance for the Investigational New Drug (IND) application of BX-U001, a product derived from umbilical cord mesenchymal stem cells. This clearance enables further investigation in patients with Rheumatoid Arthritis.

Key Market Players

  • Biorestorative Therapies Inc.
  • Celgene corporation
  • ReNeuron Group plc
  • Opexa Therapeutics, Inc.
  • Pluristem Therapeutics Inc
  • STEMCELL Technologies Inc.
  • Biovault family
  • Precious Cells International Ltd
  • Mesoblast Ltd
  • Seneca Biopharmaceuticals, Inc.

By Type

By Cell Source

By Application

By End User

By Region
  • Allogenic Transplants
  • Autologous Transplants
  • Adipose Tissue-Derived Mesenchymal Stem Cells
  • Bone Marrow-Derived Mesenchymal Stem Cells
  • Cord Blood/Embryonic Stem Cells  
  • Cancer
  • Musculoskeletal Disorder
  • Wounds and Injuries
  • Cardiovascular Disease
  • Others
  • Hospitals and Surgical Centers
  • Therapeutic Companies
  • North America
  • Europe
  • Asia Pacific
  • South America
  • Middle East & Africa

 

Report Scope:

In this report, the Global Stem Cell Therapy Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

  • Stem Cell Therapy Market, By Type:

o   Allogenic Transplants

o   Autologous Transplants

  • Stem Cell Therapy Market, By Cell Source:

o   Adipose Tissue-Derived Mesenchymal Stem Cells

o   Bone Marrow-Derived Mesenchymal Stem Cells

o   Cord Blood/Embryonic Stem Cells

  • Stem Cell Therapy Market, By Application:

o   Cancer

o   Musculoskeletal Disorder

o   Wounds and Injuries

o   Cardiovascular Disease

o   Others

  • Stem Cell Therapy Market, By End User:

o   Hospitals and Surgical Centres

o   Therapeutic Companies

  • Stem Cell Therapy Market, By Region:

o   North America

§  United States

§  Canada

§  Mexico

o   Europe

§  France

§  United Kingdom

§  Italy

§  Germany

§  Spain

o   Asia-Pacific

§  China

§  India

§  Japan

§  Australia

§  South Korea

o   South America

§  Brazil

§  Argentina

§  Colombia

o   Middle East & Africa

§  South Africa

§  Saudi Arabia

§  UAE

§  Kuwait

§  Turkey

§  Egypt

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Stem Cell Therapy Market.

Available Customizations:

Global Stem Cell Therapy market report with the given market data, Tech Sci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

Company Information

  • Detailed analysis and profiling of additional market players (up to five).

Global Stem Cell Therapy Market is an upcoming report to be released soon. If you wish an early delivery of this report or want to confirm the date of release, please contact us at [email protected]

Table of content

1.    Service Overview

2.    Research Methodology

3.    Executive Summary

4.    Voice of Customer

5.    Global Stem Cell Therapy Market Outlook

5.1.  Market Size & Forecast

5.1.1.    By Value

5.2.  Market Share & Forecast

5.2.1.    By Type (Allogenic Transplants, Autologous Transplants)

5.2.2.    By Cell Source (Adipose Tissue-Derived Mesenchymal Stem Cells, Bone Marrow-Derived Mesenchymal Stem Cells, Cord Blood/Embryonic Stem Cells)

5.2.3.    By Application (Cancer, Musculoskeletal Disorder, Wounds and Injuries, Cardiovascular Disease, Others)

5.2.4.    By End User (Hospitals and Surgical Centres, Therapeutic Companies)

5.2.5.    By Region

5.2.6.    By Company (2022)

5.3.  Market Map

6.    North America Stem Cell Therapy Market Outlook

6.1.  Market Size & Forecast

6.1.1.    By Value

6.2.  Market Share & Forecast

6.2.1.    By Type

6.2.2.    By Cell Source

6.2.3.    By Application

6.2.4.    By End User

6.2.5.    By Country

6.3.  North America: Country Analysis

6.3.1.    United States Stem Cell Therapy Market Outlook

6.3.1.1.        Market Size & Forecast

6.3.1.1.1.           By Value

6.3.1.2.        Market Share & Forecast

6.3.1.2.1.           By Type

6.3.1.2.2.           By Cell Source

6.3.1.2.3.           By Application

6.3.1.2.4.           By End User

6.3.2.    Canada Stem Cell Therapy Market Outlook

6.3.2.1.        Market Size & Forecast

6.3.2.1.1.           By Value

6.3.2.2.        Market Share & Forecast

6.3.2.2.1.           By Type

6.3.2.2.2.           By Cell Source

6.3.2.2.3.           By Application

6.3.2.2.4.           By End User

6.3.3.    Mexico Stem Cell Therapy Market Outlook

6.3.3.1.        Market Size & Forecast

6.3.3.1.1.           By Value

6.3.3.2.        Market Share & Forecast

6.3.3.2.1.           By Type

6.3.3.2.2.           By Cell Source

6.3.3.2.3.           By Application

6.3.3.2.4.           By End User

7.    Europe Stem Cell Therapy Market Outlook

7.1.  Market Size & Forecast

7.1.1.    By Value

7.2.  Market Share & Forecast

7.2.1.    By Type

7.2.2.    By Cell Source

7.2.3.    By Application

7.2.4.    By End User

7.2.5.    By Country

7.3.  Europe: Country Analysis

7.3.1.    Germany Stem Cell Therapy Market Outlook

7.3.1.1.        Market Size & Forecast

7.3.1.1.1.           By Value

7.3.1.2.        Market Share & Forecast

7.3.1.2.1.           By Type

7.3.1.2.2.           By Cell Source

7.3.1.2.3.           By Application

7.3.1.2.4.           By End User

7.3.2.    United Kingdom Stem Cell Therapy Market Outlook

7.3.2.1.        Market Size & Forecast

7.3.2.1.1.           By Value

7.3.2.2.        Market Share & Forecast

7.3.2.2.1.           By Type

7.3.2.2.2.           By Cell Source

7.3.2.2.3.           By Application

7.3.2.2.4.           By End User

7.3.3.    Italy Stem Cell Therapy Market Outlook

7.3.3.1.        Market Size & Forecast

7.3.3.1.1.           By Value

7.3.3.2.        Market Share & Forecast

7.3.3.2.1.           By Type

7.3.3.2.2.           By Cell Source

7.3.3.2.3.           By Application

7.3.3.2.4.           By End User

7.3.4.    France Stem Cell Therapy Market Outlook

7.3.4.1.        Market Size & Forecast

7.3.4.1.1.           By Value

7.3.4.2.        Market Share & Forecast

7.3.4.2.1.           By Type

7.3.4.2.2.           By Cell Source

7.3.4.2.3.           By Application

7.3.4.2.4.           By End User

7.3.5.    Spain Stem Cell Therapy Market Outlook

7.3.5.1.        Market Size & Forecast

7.3.5.1.1.           By Value

7.3.5.2.        Market Share & Forecast

7.3.5.2.1.           By Type

7.3.5.2.2.           By Cell Source

7.3.5.2.3.           By Application

7.3.5.2.4.           By End User

8.    Asia-Pacific Stem Cell Therapy Market Outlook

8.1.  Market Size & Forecast

8.1.1.    By Value

8.2.  Market Share & Forecast

8.2.1.    By Type

8.2.2.    By Cell Source

8.2.3.    By Application

8.2.4.    By End User

8.2.5.    By Country

8.3.  Asia-Pacific: Country Analysis

8.3.1.    China Stem Cell Therapy Market Outlook

8.3.1.1.        Market Size & Forecast

8.3.1.1.1.           By Value

8.3.1.2.        Market Share & Forecast

8.3.1.2.1.           By Type

8.3.1.2.2.           By Cell Source

8.3.1.2.3.           By Application

8.3.1.2.4.           By End User

8.3.2.    India Stem Cell Therapy Market Outlook

8.3.2.1.        Market Size & Forecast

8.3.2.1.1.           By Value

8.3.2.2.        Market Share & Forecast

8.3.2.2.1.           By Type

8.3.2.2.2.           By Cell Source

8.3.2.2.3.           By Application

8.3.2.2.4.           By End User

8.3.3.    Japan Stem Cell Therapy Market Outlook

8.3.3.1.        Market Size & Forecast

8.3.3.1.1.           By Value

8.3.3.2.        Market Share & Forecast

8.3.3.2.1.           By Type

8.3.3.2.2.           By Cell Source

8.3.3.2.3.           By Application

8.3.3.2.4.           By End User

8.3.4.    South Korea Stem Cell Therapy Market Outlook

8.3.4.1.        Market Size & Forecast

8.3.4.1.1.           By Value

8.3.4.2.        Market Share & Forecast

8.3.4.2.1.           By Type

8.3.4.2.2.           By Cell Source

8.3.4.2.3.           By Application

8.3.4.2.4.           By End User

8.3.5.    Australia Stem Cell Therapy Market Outlook

8.3.5.1.        Market Size & Forecast

8.3.5.1.1.           By Value

8.3.5.2.        Market Share & Forecast

8.3.5.2.1.           By Type

8.3.5.2.2.           By Cell Source

8.3.5.2.3.           By Application

8.3.5.2.4.           By End User

9.    South America Stem Cell Therapy Market Outlook

9.1.  Market Size & Forecast

9.1.1.    By Value

9.2.  Market Share & Forecast

9.2.1.    By Type

9.2.2.    By Application

9.2.3.    By Cell Source

9.2.4.    By End User

9.2.5.    By Country

9.3.  South America: Country Analysis

9.3.1.    Brazil Stem Cell Therapy Market Outlook

9.3.1.1.        Market Size & Forecast

9.3.1.1.1.           By Value

9.3.1.2.        Market Share & Forecast

9.3.1.2.1.           By Type

9.3.1.2.2.           By Cell Source

9.3.1.2.3.           By Application

9.3.1.2.4.           By End User

9.3.2.    Argentina Stem Cell Therapy Market Outlook

9.3.2.1.        Market Size & Forecast

9.3.2.1.1.           By Value

9.3.2.2.        Market Share & Forecast

9.3.2.2.1.           By Type

9.3.2.2.2.           By Cell Source

9.3.2.2.3.           By Application

9.3.2.2.4.           By End User

9.3.3.    Colombia Stem Cell Therapy Market Outlook

9.3.3.1.        Market Size & Forecast

9.3.3.1.1.           By Value

9.3.3.2.        Market Share & Forecast

9.3.3.2.1.           By Type

9.3.3.2.2.           By Cell Source

9.3.3.2.3.           By Application

9.3.3.2.4.           By End User

10. Middle East and Africa Stem Cell Therapy Market Outlook

10.1.   Market Size & Forecast        

10.1.1. By Value

10.2.   Market Share & Forecast

10.2.1. By Type

10.2.2. By Cell Source

10.2.3. By Application

10.2.4. By End User

10.2.5. By Country

10.3.   MEA: Country Analysis

10.3.1. South Africa Stem Cell Therapy Market Outlook

10.3.1.1.     Market Size & Forecast

10.3.1.1.1.         By Value

10.3.1.2.     Market Share & Forecast

10.3.1.2.1.         By Type

10.3.1.2.2.         By Cell Source

10.3.1.2.3.         By Application

10.3.1.2.4.         By End User

10.3.2. Saudi Arabia Stem Cell Therapy Market Outlook

10.3.2.1.     Market Size & Forecast

10.3.2.1.1.         By Value

10.3.2.2.     Market Share & Forecast

10.3.2.2.1.         By Type

10.3.2.2.2.         By Cell Source

10.3.2.2.3.         By Application

10.3.2.2.4.         By End User

10.3.3. UAE Stem Cell Therapy Market Outlook

10.3.3.1.     Market Size & Forecast

10.3.3.1.1.         By Value

10.3.3.2.     Market Share & Forecast

10.3.3.2.1.         By Type

10.3.3.2.2.         By Cell Source

10.3.3.2.3.         By Application

10.3.3.2.4.         By End User

11. Market Dynamics

12. Market Trends & Developments

13. Global Stem Cell Therapy Market: SWOT Analysis

14. Competitive Landscape

14.1.   Business Overview

14.2.   Application Offerings

14.3.   Recent Developments

14.4.   Key Personnel

14.5.   SWOT Analysis

14.5.1. Biorestorative Therapies Inc.

14.5.2. Celgene corporation

14.5.3. ReNeuron Group plc

14.5.4. Opexa Therapeutics, Inc.

14.5.5. Pluristem Therapeutics Inc

14.5.6. STEMCELL Technologies Inc.

14.5.7. Biovault family

14.5.8. Precious Cells International Ltd

14.5.9. Mesoblast Ltd

14.5.10.              Seneca Biopharmaceuticals, Inc.

15. Strategic Recommendations

16. About Us & Disclaimer

Figures and Tables

Frequently asked questions

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The market size of the Global Stem Cell Therapy Market was estimated to be USD 261.07 Million in 2022.

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Based on type, the allogenic therapy segment currently dominates the market due to its cost-effectiveness and ready availability. Allogenic stem cell therapy involves the transfer of stem cells from a healthy donor to the patient's body after intense chemotherapy or radiation treatment. Allogenic therapy utilizes unrestricted cell doses of biologically compatible cells, eliminating concerns about donor variability. This segment is expected to experience significant growth in the coming years, primarily due to its diverse applications in supporting cancer treatments, specifically for conditions such as leukemia, lymphoma, and myeloma.

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North America has emerged as the dominant player in the stem cell market, with the United States contributing the largest market share. The United States and Canada boast well-structured healthcare systems that not only support but also encourage research and development. The rising incidence of cancer cases presents lucrative opportunities for market players. To capitalize on this, major market players are intensifying their focus on research and development activities to introduce novel stem cell therapies. Furthermore, as per the American Cancer Society, the United States witnessed an estimated 1,918,030 new cancer cases and reported 609,360 deaths in 2022. It is noteworthy that prostate cancer is the leading cancer site among males, while breast cancer prevails among females. The escalating burden of this disease is expected to drive the growth of the market.

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Increasing adoption of cell-based therapies and expanding clinical applications are the major drivers for the Global Stem Cell Therapy Market.

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Sakshi Bajaal

Business Consultant
Press Release

Global Stem Cell Therapy Market to Grow with a CAGR of 12.39% through 2028

Aug, 2023

Increasing technological advancement in stem cell therapeutics and surging demand for stem cell therapy is expected to drive the global stem cell therapy market growth in the forecast period, 2024-20

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