The International Scientific Association for Probiotics and Prebiotics defines probiotics as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host.” These microorganisms, primarily bacteria but also including yeasts, are found in some fermented foods (like yogurt), added to certain food products, and available as dietary supplements. However, not all foods and dietary supplements that are labeled as probiotics have proven health benefits.

According to TechSci Research report “Probiotics Dietary Supplements Market - Global Industry Size, Share, Trends, Opportunity & Forecast, Segmented By Form (Chewables & Gummies, Capsules, Powders, Tablets & Softgels, Others), By End-use (Infants, Children, Adults, Geriatric), By Applications (Sports Fitness, Energy & Weight Management, General Health, Bone & Joint Health, Gastrointestinal Health, Immunity, Cardiac Health, Diabetes, Anti-cancer, Skin/Hair/Nails, Brain/Mental Health, Others), By Region, & Competition, 2020-2030F” Global Probiotics Dietary Supplements Market was valued at USD 8.76 Billion in 2024 and is anticipated to project impressive growth in the forecast period with a CAGR of 10.75% through 2030.

Probiotic dietary supplements can contain a single strain or multiple strains of live microorganisms. The number of viable cells in a probiotic supplement is indicated by the number of colony-forming units (CFU) listed on the label. However, it can be difficult to determine which products offer verifiable health benefits due to the wide variety of probiotic strains and doses found in probiotic products and inconsistent labeling practices and recommendations for use.

Probiotics are offered as dietary supplements in various forms, such as capsules, powders, liquids, and more, containing a wide variety of strains and doses. These supplements may feature either a single strain or a combination of multiple live microorganisms. The effects of many commercial products that contain probiotics have not been examined in research studies, and it is difficult for people who are not familiar with probiotic research to determine which products are backed by evidence. However, some organizations have systematically reviewed the available evidence and developed recommendations for using specific probiotics, including the appropriate product, dose, and formulation, to prevent or treat various health conditions.  

Probiotics are measured in CFU, which stands for colony-forming units, which is just a way of counting how many live, active microorganisms are in the product. You’ll often see numbers like 1 x 10⁹ (which means 1 billion CFU) or 1 x 10¹⁰ (10 billion CFU) on the label. Most supplements contain somewhere between 1 and 10 billion CFU per serving, though some go as high as 50 billion or more. But more is not always better, a higher CFU count does not necessarily mean the product will be more effective.

Current labeling regulations only require manufacturers to list the total weight of microorganisms on the Supplement Facts label of probiotic products. However, this weight includes both live and dead microorganisms, so it does not reflect how many viable microbes are present. Some manufacturers choose to include the CFU count, the number of live microorganisms, in addition to the total weight. Since probiotics need to be alive to provide health benefits and can lose potency over time, it is best to choose products that list the CFU count based on the amount present at the end of the product’s shelf life, not just at the time of manufacture. 

Top 10 Probiotics Dietary Supplements Companies:

1. BioGaia

BioGaia is a world leader in probiotic research and development. Its clinically proven probiotics have been supporting the health and well-being of people everywhere, throughout every stage of life, since 1990. With a strong foundation in science and over 200 clinical studies backing its products, BioGaia specializes in strain-specific solutions, particularly Lactobacillus reuteri. The company offers targeted formulations for digestive health, immunity, oral care, and colic relief in infants, trusted by healthcare professionals in more than 100 countries.

Its Probiotic Offerings:

BioGaia Gastrus – Probiotic Chewables

BioGaia Osfortis – Probiotic Capsules

BioGaia Prodentis – Probiotic Lozenges

BioGaia Protectis MUM – Probiotic Capsules

2. Chr. Hansen Holding A/S

Hansen Holding A/S is a leading global bioscience company headquartered in Hørsholm, Denmark. The company specializes in developing natural ingredient solutions for the food, nutritional, pharmaceutical, and agricultural industries. Its product portfolio includes microbiological cultures, enzymes, probiotics, and natural colors, which play a crucial role in creating a resilient food system that minimizes climate impact. Hansen offers a comprehensive range of probiotic solutions, encompassing both human and animal health applications.

Its Probiotic Offerings:

LGG (Lactobacillus rhamnosus)

BB-12 (Bifidobacterium animalis subsp. lactis)

LA-5 (Lactobacillus acidophilus)

DDS-1 (Lactobacillus acidophilus)

L. CASEI 431 (Lactobacillus paracasei)

F-19 (Lactobacillus paracasei)

UREX

ASTARTE

LRC (Lactobacillus reuteri)

UABla-12

DSM 33361 (Bifidobacterium infantis)

PPLP-217 (Lactobacillus plantarum)

3. Yakult Honsha Co. Ltd.

Yakult Honsha Co., Ltd. is a Japanese multinational company known globally for its probiotic dairy products, especially the Yakult drink. Yakult operates in over 40 countries and regions, with a significant presence in Asia, the Americas, Europe, and Oceania. The company employs a unique home-delivery system through its network of approximately 83,000 "Yakult Ladies," who contribute to about 45% of its probiotic drink sales volume globally.

Its Probiotic Offerings:

Yakult for Happy Gut & Immunity

Yakult Light Mango Flavour

Yakult Light with Reduced Sugar

4. Danone S.A.

Danone S.A. is a French multinational food and beverage company headquartered in Paris. Founded in 1919 by Isaac Carasso in Barcelona, Spain, Danone has grown into a global leader in health-focused food products. The company operates in over 120 countries and employs approximately 96,000 people worldwide. Danone is renowned for its wide range of dairy and plant-based products, including probiotic yogurts and supplements designed to promote digestive health and overall wellness. Its flagship probiotic brand, Activia, is trusted by millions globally and supported by extensive scientific research. Committed to sustainability, Danone actively pursues environmental initiatives and aims to support healthier eating habits through innovation and responsible sourcing.

Its Probiotic Offerings:

Activia

Actimel

Alpro

YoPRO

5. Lifeway Foods

Lifeway Foods, Inc. is a leading U.S.-based producer of probiotic and cultured dairy products, best known for popularizing kefir in the American market. Headquartered in Morton Grove, Illinois, the company was founded in 1986 by Ukrainian immigrant Michael Smolyansky, who began producing kefir in his basement to introduce the traditional Eastern European fermented milk drink to the U.S. Its primary product is drinkable kefir, a cultured dairy product. Lifeway kefir is tart and tangy, high in protein, calcium, and vitamin D.

Its Probiotic Offerings:

Probiotic Smoothie + Collagen Plain

Probiotic Smoothie + Collagen Tropical Fruit

Probiotic Smoothie + Collagen Matcha Latte

Probiotic Smoothie + Collagen Berry Blast

6. Probi USA Inc.

​Probi USA Inc. is the North American subsidiary of Probi AB, a Swedish biotechnology company specializing in the development, manufacturing, and delivery of clinically proven probiotics for dietary supplements and functional foods. Its operations cover the entire value chain, from research and development to sales.

Probi USA Inc. has recently launched Weizmannia coagulans GX-1, a resilient spore-forming probiotic ideal for high-temperature and high-moisture applications in food, beverage, confectionery, and dietary supplements. In collaboration with Clasado Biosciences, Probi introduced two new synbiotic solutions combining the proven prebiotic Bimuno GOS with its clinically studied Probi Defendum and Probi Digestis strains.

Its Probiotic Offerings:

Probi Sensia

Probi Digestis

Probi Defendum

Probi Osteo mode of action

BLIS by Probi

Probi LiveBac

7. Reckitt Benckiser Group PLC

Reckitt Benckiser Group Plc offers probiotic dietary supplements under its Digestive Advantage brand. These supplements are formulated with the patented BC30 probiotic strain (Bacillus coagulans GBI-30, 6086), designed to support digestive and immune health. The BC30 strain is notable for its resilience, surviving stomach acid 100 times better than yogurt, ensuring that more live bacteria reach the gut.

Its Probiotic Offerings:

Daily Probiotic Capsules

IBS Probiotics

Prebiotic + Probiotic Gummies

8. Nestlé Health Science

Nestlé Health Science (NHSc) is a global leader in nutritional science, focused on advancing health through innovative nutrition and science-based solutions. It was created to pioneer a new approach to the management of health by integrating nutrition and therapeutic solutions. Nestlé Health Science offers a diverse range of probiotic products across various brands, catering to different health needs and life stages.

Nestlé Health Science offers a wide range of probiotic products through several brands, including Garden of Life, which provides high-potency, whole-food-based probiotics for various health needs; Nature’s Bounty, known for accessible probiotic gummies and capsules; NAN CARE, focusing on infant probiotics to support early gut health; Vital Proteins, which combines collagen with probiotics for gut support; Pure Encapsulations, offering professional-grade targeted probiotic formulas; and Persona Nutrition, delivering personalized probiotic and vitamin subscriptions tailored to individual health profiles, together reflecting Nestlé’s commitment to science-backed probiotic solutions across all life stages.

Its Probiotic Offerings:

 Garden of Life

·         Dr. Formulated Probiotics Once Daily Women

·         Dr. Formulated Probiotics Once Daily Men

·         Dr. Formulated Probiotics Mood+

·         Raw Probiotics Ultimate Care

·         Dr. Formulated Probiotics Prenatal

Nature’s Bounty

·         Nature’s Bounty Probiotic Gummies

·         Nature’s Bounty Probiotic Capsules

NAN CARE

·         NAN OPTIPRO 3 with Probiotic Drops

Vital Proteins

·         Vital Proteins Collagen Peptides with Probiotics

Pure Encapsulations

·         Probiotic 50B

·         Probiotic GI Balance

Persona Nutrition

·         Personalized probiotic supplements tailored per customer (names vary per formulation)

9. Kerry Group PLC

Kerry Group plc is a global leader in taste and nutrition innovation, headquartered in Tralee, County Kerry, Ireland. Established in 1972 as North Kerry Milk Products, the company has evolved from a regional dairy cooperative into a multinational corporation. Today, Kerry Group operates in over 140 countries, employing approximately 23,000 people worldwide.

Its Probiotic Offerings:

Bio-K+ Daily Care Probiotic Capsules

Bio-K+ Extra Strength Capsules

Bio-K+ Fermented Probiotic Drinkable – Original

Bio-K+ Fermented Probiotic Drinkable – Organic

Bio-K+ Fermented Probiotic Drinkable – Non-Dairy (Soy or Rice-based)

10. Amway

​Amway Corp. (Amway), a subsidiary of Alticor Global Holdings Inc, is a manufacturer, retailer and distributer of nutrition, beauty and body and bath products. Nutrilite is Amway’s flagship health and wellness brand. It offers a wide variety of products to support immunity & overall health of individuals. Nutrilite is the world's number one selling vitamins & dietary supplements brand.

Its Probiotic Offerings:

Nutrilite Balance Within Probiotic

Nutrilite Stress Relief Probiotic

Nutrilite Begin Daily GI Primer

Nutrilite Pre and Probiotic Capsules

How to Choose a Good Probiotic Supplement?

Not all probiotics are created equal. With countless options on the market, it is important to know how to evaluate quality before making a purchase.

Strain Diversity: A quality probiotic should list specific strains (e.g., Lactobacillus rhamnosus GG, not just “Lactobacillus”). Multiple strains may offer broader health benefits—like improving digestion, boosting immunity, or balancing mood—because different strains perform different functions in the gut.

CFU Count (Colony Forming Units): More is not always better. A good probiotic typically contains 1 to 10 billion CFUs per serving for general health, though higher doses may be helpful for specific conditions. What matters more is whether the strains survive and thrive in your digestive tract.

Delivery Method: Probiotics come in capsules, tablets, powders, gummies, and even drinks. Look for options that suit your lifestyle—and protect the bacteria. Delayed-release capsules or enteric coatings help probiotics survive stomach acid and reach your gut alive.

Refrigeration & Shelf-Stability: Some probiotics require refrigeration, while others use shelf-stable technology (like freeze-drying or spore-forming strains). Choose according to your storage situation and travel needs—but always check the label for expiration details.

Conclusion:

The top ten probiotic supplement companies featured in this blog include industry leaders like BioGaia, Chr. Hansen Holding A/S, Yakult Honsha Co. Ltd., Danone S.A., Lifeway Foods, Probi USA Inc., Reckitt Benckiser Group PLC, Nestlé Health Science, Kerry Group PLC, and Amway. These companies offer a wide range of probiotic supplements in various forms—including capsules, powders, drinks, and gummies—designed to support gut health, immunity, and overall wellness.

Backed by extensive research and clinical trials, many of these brands focus on delivering specific probiotic strains targeted at improving digestion, enhancing immune response, and even supporting mental well-being. With growing consumer awareness about gut health, these companies continue to innovate by developing personalized probiotic solutions, incorporating prebiotics and postbiotics, and expanding into dairy-free and vegan-friendly formulations to cater to diverse dietary needs.

In addition, these companies emphasize quality control, using advanced manufacturing processes and third-party testing to guarantee potency and purity. As consumer demand grows for natural and sustainable products, many are also incorporating organic, non-GMO, and plant-based ingredients. Together, these top probiotic supplement companies play a vital role in advancing gut health awareness and providing trusted solutions to millions worldwide.