Report Description

United States CAR-T Cell Therapy Market is expected to grow at an impressive rate during the forecast period, 2024-2028. The major factors include rising prevalence of cancer consisting of myeloma, lymphoma, leukemia, etc., rapidly expanding clinical trial activities, rise in awareness of CAR T cell therapy, and recent commercialization of CAR-T cell therapy.

CAR-T (Chimeric Antigen Receptor T-cell) therapy is an innovative type of immunotherapy that involves genetically modifying a patient's own T- cells to recognize and attack cancer cells. This therapy has shown remarkable results in the treatment of certain types of blood cancer, such as acute lymphoblastic leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL). According to Leukemia and Lymphoma Society, in 2021, an estimated 34,920 new cases of myeloma (19,320 males and 15,600 females) were expected to be diagnosed in the United States (U.S.), and an estimated 138,415 people are living with myeloma in U.S. Additionally, in 2021, 61,090 people were expected to be diagnosed with leukemia in the U.S., and an estimated 397,501 people are living with leukemia in the U.S.

The Chimeric Antigen Receptor (CAR) T-cell therapy is for the treatment of hematologic malignancies i.e., the cancers that begin in blood-forming tissue, such as the bone marrow, or in the cells of the immune system like leukemia, lymphoma, and multiple myeloma, etc. Another factor driving the market growth is the increasing demand for personalized and targeted cancer therapies. CAR-T cell therapy is a highly personalized treatment that involves modifying the patient's immune cells to target cancer cells, making it a more effective and precise treatment option for certain types of cancers.

According to Global Cancer Observatory, in 2020, around 1 0,55,117 new cancer cases were reported in United States of America. Moreover, the other factor includes the increasing investments on healthcare sector, major involvement of market players, and increase in number of funding activities. Various initiatives and awareness programs are taken by government or private organization to raise awareness about diseases and treatments,  and information about the availability of more advanced technologies and procedures at healthcare facilities.

Rising Prevalence of Cancer

In United States, cancer is the leading cause of death. This is due to the physical carcinogens, such as ultraviolet and ionizing radiation, chemical carcinogens, such as asbestos, components of tobacco smoke, alcohol, aflatoxin (a food contaminant), and arsenic (a drinking water contaminant) and biological carcinogens, such as infections from certain viruses, bacteria, or parasites, and unhealthy lifestyle. According to American Cancer Society, more than 1.8 million people were diagnosed with cancer in 2020.  For instance, an estimated 1,519,907 people in the United States are suffering with leukemia, lymphoma, myeloma, myelodysplastic syndromes (MDS) or myeloproliferative neoplasms (MPNs). Therefore, the CAR-T Cell therapy enables the T cells to target cell surface antigen for getting management and treatment for cancer. Thereby, it is expected to drive the growth of the CAR-T Cell Therapy Market in United States. 

Recent Developments

In 2017, the first two autologous CAR T-cell therapies were approved by the US Food and Drug Administration namely tisagenlecleucel (Kymriah) for the treatment of patients up to 25 years of age with large B-cell lymphoma (refractory or in second or later relapse), and axicabtagene ciloleucel (Yescarta), for the treatment of adults with large B-cell lymphoma (LBCL) who either did not respond to first-line standard chemotherapy or relapsed within 12 months of chemotherapy .

In 2020, the FDA had given the approval for brexucabtagene autoleucel (TecartusTM) or the treatment of adults with r/r MCL and adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).

Additionally, in 2021, the FDA had given the approval for Lisocabtagene maraleucel (Breyanzi) or the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy and idecabtagene vicleucel (Abecma) for the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy.

Recently, in March 2022, Ciltacabtagene autoleucel (CarvyktiTM) were approved by FDA for the treatment of adult patients with relapsed or refractory multiple myeloma who have already tried four or more prior lines of therapy.

Commercialization of CAR-T Cell Therapy

The commercialization of CAR-T Cell Therapy is the key challenge resulting in restricting the growth of the market in the forecast period. This is due to the complex manufacturing and supply chain, high-touch commercial model, and reimbursement cost. All CAR T-cell therapies are autologous, resulting in complex, costly manufacturing and supply chains. For instance, in the United States, a limited number of certified academic medical centers (AMCs) offers commercial CAR T, often requiring patients to travel long distances to receive care. This is due to the limited number of commercial sites which involves extensive preparation and certification to offer CAR T therapies.

Increasing Investments in Research and Development & Favorable Regulatory Environment

Research and development are crucial for the advancement of CAR-T cell therapy. The United States has a significant advantage in this regard, as it is home to some of the world's leading research institutions and pharmaceutical companies. These companies are investing heavily in CAR-T cell therapy research, which is driving the market's growth. Additionally, the FDA discovered an improved environment to give approval of two CAR-T cell therapies for use in the United States, which has provided a boost to the market. The regulatory environment for CAR-T cell therapy is favorable, which has encouraged more companies to invest in this area. The FDA's expedited review process for breakthrough therapies has helped speed up the approval process for CAR-T cell therapies, which has contributed to market growth.


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Market Segmentation

The United States CAR-T Cell Therapy Market can be segmented into product type, tumor type, indication, treatment type, targeted antigen, end user, and region. By product type, the market can be segmented into Yescarta (Axicabtagene Ciloleucel), Kymriah (Tisagenlecleucel), Tecartus (Brexucabtagene Autoleucel), Breyanzi (Lisocabtagene Maraleucel), Abecma (Idecabtagene Vicleucel), and others. Based on tumor type, the market can be segmented into Hematological Malignancies, and Solid Tumors. Based on indication, the market can be segmented into Diffused Large B-Cell Lymphoma (DLBCL), Acute Lymphoblastic Leukemia (ALL), Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), and Others. Based on treatment type, the market can be segmented into Single Treatment and Combination Treatment. Based on targeted antigen, the market can be segmented into CD 19, BCMA (B-Cell Maturation Antigen), and Others. Based on end user, the market can be segmented into Hospitals, Specialty Clinics, Ambulatory Surgical Centers, and Others.

Market Players

Gilead Sciences, Inc (US), Novartis United States, AbbVie Inc., Myriad Genetics, NeoGenomics Laboratories, Intellia Therapeutics (US), Agilent Technologies, Inc. (US), Abcam plc., Bio-Techne. (ExoDx), Sangamo Therapeutics, Inc. (US) etc. are some of the leading companies operating in the market.

Attribute

Details

Base Year

2022

Historic Data

2018 – 2022

Estimated Year

2023

Forecast Period

2024 – 2028

Quantitative Units

Revenue in USD Million, Volume Units and CAGR for 2018-2022 and 2023-2028

Report coverage

Revenue forecast, Volume forecast company share, competitive landscape, growth factors, and trends

Segments covered

Product Type

Tumor Type

Indication

Treatment Type

Targeted Antigen

End User

Region

Company

Regional scope

 Northeast Region, Midwest Region, South Region, West Region

Key companies profiled

Gilead Sciences, Inc (US), Novartis United States, AbbVie Inc., Myriad Genetics, NeoGenomics Laboratories, Intellia Therapeutics (US), Agilent Technologies, Inc. (US), Abcam plc., Bio-Techne. (ExoDx), Sangamo Therapeutics, Inc. (US).

Customization scope

10% free report customization with purchase. Addition or alteration to country, regional & segment scope.

Pricing and purchase options

Avail customized purchase options to meet your exact research needs. Explore purchase options

Delivery Format

PDF and Excel through Email (We can also provide the editable version of the report in PPT/Word format on special request)


Report Scope:

In this report, United States CAR-T Cell Therapy Market has been segmented into following categories, in addition to the industry trends which have also been detailed below:

        ·         United States CAR-T Cell Therapy Market, By Product Type

o    Yescarta (Axicabtagene Ciloleucel)

o    Kymriah (Tisagenlecleucel)

o    Tecartus (Brexucabtagene Autoleucel)

o    Breyanzi (Lisocabtagene Maraleucel)

o    Abecma (Idecabtagene Vicleucel)

o    Others

        ·         United States CAR-T Cell Therapy Market, Tumor Type

o    Hematological Malignancies

o    Solid Tumors

        ·         United States CAR-T Cell Therapy Market, By Indication

o    Diffused Large B-Cell Lymphoma (DLBCL)

o    Acute Lymphoblastic Leukemia (ALL)

o    Follicular Lymphoma (FL)

o    Mantle Cell Lymphoma (MCL)

o    Others

        ·         United States CAR-T Cell Therapy Market, By Treatment Type

o    Single Treatment

o    Combination Treatment

        ·         United States CAR-T Cell Therapy Market, By Targeted Antigen

o    CD 19

o    BCMA (B-Cell Maturation Antigen)

o    Others

        ·         United States CAR-T Cell Therapy Market, By End User

o    Hospitals

o    Specialty Clinics

o    Ambulatory Surgical Centers

o    Others

        ·         United States CAR-T Cell Therapy Market, By Region:

o    Northeast

o    Midwest

o    South

o    West

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in United States CAR-T Cell Therapy Market

Available Customizations:

With the given market data, TechSci Research offers customizations according to a company’s specific needs. The following customization options are available for the report:

Company Information:

  • Detailed analysis and profiling of additional market players (up to five).

United States CAR-T Cell Therapy Market is an upcoming report to be released soon. If you wish an early delivery of this report or want to confirm the date of release, please contact us at [email protected]

Table of content

1.    Product Overview

1.1.  Market Definition

1.2.  Scope of the Market

1.2.1.     Markets Covered

1.2.2.     Years Considered for Study

1.2.3.     Key Market Segmentations

2.    Research Methodology

2.1.  Objective of the Study

2.2.  Baseline Methodology

2.3.  Key Industry Partners

2.4.  Major Association and Secondary Sources

2.5.  Forecasting Methodology

2.6.  Data Triangulation & Validation

2.7.  Assumptions and Limitations

3.    Executive Summary

3.1.  Overview of the Market

3.2.  Overview of Key Market Segmentations

3.3.  Overview of Key Market Players

3.4.  Overview of Key Regions/Countries

3.5.  Overview of Market Drivers, Challenges, Trends

4.    Voice of Customer

5.    Clinical Trial Analysis

5.1.  Ongoing Clinical Trials

5.2.  Completed Clinical Trials

5.3.  Terminated Clinical Trials

5.4.  Breakdown of Pipeline, By Development Phase

5.5.  Breakdown of Pipeline, By Status

5.6.  Breakdown of Pipeline, By Study Application

5.7.  Breakdown of Pipeline, By Region

5.8.  Clinical Trials Heat Map

6.    U.S. CAR-T Cell Therapy Market Outlook

6.1.  Market Size & Forecast

6.1.1.     By Value

6.2.  Market Share & Forecast

6.2.1.   By Product Type (Yescarta (Axicabtagene Ciloleucel), Kymriah (Tisagenlecleucel), Tecartus (Brexucabtagene Autoleucel), Breyanzi (Lisocabtagene Maraleucel), Abecma (Idecabtagene Vicleucel), Others)

6.2.2.   By Tumor Type (Hematological Malignancies, Solid Tumors)

6.2.3.   By Indication (Diffused Large B-Cell Lymphoma (DLBCL), Acute Lymphoblastic Leukemia (ALL), Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Others)

6.2.4.   By Treatment Type (Single Treatment, Combination Treatment)

6.2.5.   By Targeted Antigen (CD 19, BCMA (B-Cell Maturation Antigen), Others)

6.2.6.   By End User (Hospitals, Specialty Clinics, Ambulatory Surgical Centers, Others)

6.2.7.   By Region (Northeast Region, Midwest Region, South Region, West Region)

6.2.8.   By Company (2022)

6.3.  Market Map

6.3.1.     By Product Type

6.3.2.     By Tumor Type

6.3.3.     By Indication

6.3.4.     By Treatment Type

6.3.5.     By Targeted Antigen

6.3.6.     By End User

6.3.7.     By Region

7.    North-East CAR-T Cell Therapy Market Outlook

7.1.  Market Size & Forecast          

7.1.1.     By Value

7.2.  Market Share & Forecast

7.2.1.     By Product Type

7.2.2.     By Tumor Type

7.2.3.     By Indication

7.2.4.     By Treatment Type

7.2.5.     By Targeted Antigen

7.2.6.     By End User

8.    Mid-West CAR-T Cell Therapy Market Outlook

8.1.  Market Size & Forecast          

8.1.1.     By Value

8.2.  Market Share & Forecast

8.2.1.     By Product Type

8.2.2.     By Tumor Type

8.2.3.     By Indication

8.2.4.     By Treatment Type

8.2.5.     By Targeted Antigen

8.2.6.     By End User

9.    South CAR-T Cell Therapy Market Outlook

9.1.  Market Size & Forecast          

9.1.1.     By Value

9.2.  Market Share & Forecast

9.2.1.     By Product Type

9.2.2.     By Tumor Type

9.2.3.     By Indication

9.2.4.     By Treatment Type

9.2.5.     By Targeted Antigen

9.2.6.     By End User

10.  West CAR-T Cell Therapy Market Outlook

10.1.              Market Size & Forecast

10.1.1.  By Value

10.2.              Market Share & Forecast

10.2.1.  By Product Type

10.2.2.  By Tumor Type

10.2.3.  By Indication

10.2.4.  By Treatment Type

10.2.5.  By Targeted Antigen

10.2.6.  By End User

11.  Market Dynamics

11.1.              Drivers

11.1.1.  Rising Prevalence of Cancer

11.1.2.  Recent Developments

11.2.              Challenges

11.3.              Commercialization of CAR-T Cell Therapy

11.4.              Lack of Skilled Personnels

11.5.              Higher cost of the therapy

12.  Market Trends & Developments

13.  Competitive Landscape

13.1.              Business Overview

13.2.              Product Offerings

13.3.              Recent Developments

13.4.              Financials (In Case of Listed Companies)

13.5.              Key Personnel

13.5.1.                Gilead Sciences, Inc (US)

13.5.2.                Novartis United States

13.5.3.                AbbVie Inc.

13.5.4.                Myriad Genetics

13.5.5.                NeoGenomics Laboratories

13.5.6.                Intellia Therapeutics (US)

13.5.7.                Agilent Technologies, Inc. (US)

13.5.8.                Abcam plc.

13.5.9.                Bio-Techne. (ExoDx)

13.5.10.             Sangamo Therapeutics, Inc. (US)

14.  Strategic Recommendations

Figures and Tables

Frequently asked questions

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United States CAR-T Cell Therapy Market is expected to grow at an impressive rate by 2028 on account of increasing prevalence of cancer, favorable reimbursement policies, and rise in awareness of CAR-T cell therapy.

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By tumor type, United States CAR-T Cell Therapy Market is expected to be dominated by the hematological cancer segment due to rising cases of blood cancer.

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Gilead Sciences, Inc (US), Novartis United States, AbbVie Inc., Myriad Genetics, NeoGenomics Laboratories, Intellia Therapeutics (US), Agilent Technologies, Inc. (US), Abcam plc., Bio-Techne. (ExoDx), Sangamo Therapeutics, Inc. (US) etc., are some of the leading players operating in United States CAR-T Cell Therapy Market.

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The commercialization, lack of skilled professionals, and higher cost of the therapy is hindering the market growth in the United States.