Organ Preservation Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Solution (University of Wisconsin Solution (UW Solution), Custodial HTK, Perfadex, Other Solutions), By Technique (Static Cold Storage, Hypothermic Machine Perfusion, Normothermic Machine Perfusion), By Organ Type (Kidney, Liver, Lung, Heart, Pancreas), By End User (Organ Transplant Centers, Hospitals, Specialty Clinics), By Region and Competition, 2021-2031F

Forecast Period	2027-2031
Market Size (2025)	USD 284.81 Million
CAGR (2026-2031)	5.25%
Fastest Growing Segment	University of Wisconsin Solution (UW Solution)
Largest Market	North America
Market Size (2031)	USD 387.16 Million

Market Overview

The Global Organ Preservation Market will grow from USD 284.81 Million in 2025 to USD 387.16 Million by 2031 at a 5.25% CAGR. The Global Organ Preservation Market encompasses specialized chemical solutions and mechanical perfusion systems engineered to maintain the cellular viability and physiological function of donor organs during transport and storage. The primary drivers fueling market expansion include the escalating global prevalence of chronic diseases such as diabetes and cardiovascular disorders, which significantly increase the incidence of end-stage organ failure. Furthermore, the growing geriatric population and clinical advancements that permit the utilization of higher-risk donor organs are substantially boosting the demand for effective preservation modalities to ensure successful post-transplant outcomes.

Despite this positive trajectory, a significant challenge impeding broader market potential is the persistent disparity between the high demand for transplants and the limited supply of suitable donor organs. This supply shortage restricts the total volume of procedures performed, effectively capping the addressable market for preservation technologies. According to the United Network for Organ Sharing, in 2024, a record 48,149 organ transplants were performed in the United States, representing a 3.3 percent increase over the previous year, yet this volume remains insufficient to address the overwhelming waiting list of patients requiring life-saving interventions.

Key Market Drivers

Rapid technological advancements in hypothermic and normothermic machine perfusion are fundamentally altering the sector by extending organ viability beyond the limitations of traditional static cold storage. These mechanical systems allow for the continuous metabolic support and monitoring of organs during transport, significantly reducing ischemic injury and enabling the usage of organs from extended criteria donors that were previously deemed unsuitable. The commercial adoption of these dynamic preservation technologies is accelerating, evidenced by the substantial financial growth of companies specializing in these platforms. According to TransMedics Group, Inc., October 2024, in the 'Third Quarter 2024 Financial Results', net revenue reached USD 108.8 million, marking a 64 percent increase compared to the comparable period in the prior year, driven primarily by the higher utilization of their proprietary organ care systems.

Concurrently, supportive government initiatives and national strategies aimed at increasing donor registration rates are expanding the volume of procedures requiring preservation solutions. By optimizing donation pathways and investing in infrastructure, health authorities are successfully elevating the availability of organs for transplantation, thereby necessitating a parallel increase in the consumption of preservation consumables and transport units. For instance, according to NHS Blood and Transplant, July 2024, in the 'Organ Donation and Transplantation Activity Report 2023/24', the number of deceased donors in the United Kingdom rose to 1,510, representing a 6 percent increase from the previous fiscal year. This expansion in clinical activity is fostering significant market consolidation; according to Getinge AB, in 2024, the company signed an agreement to acquire Paragonix Technologies for an estimated USD 477 million to integrate advanced preservation devices into its broader medical portfolio.

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Key Market Challenges

The critical shortage of suitable donor organs represents a formidable challenge hampering the Global Organ Preservation Market. This persistent disparity between the high demand for transplantation and the finite supply of organs effectively places a hard cap on the industry's growth trajectory. Since preservation technologies are only required when an organ is available for transport, the market's expansion is intrinsically tied to donation rates rather than the prevalence of end-stage organ failure. Consequently, the addressable market for these specialized solutions and perfusion systems remains constrained by the limited volume of procedures performed.

The magnitude of this gap is substantial and highlights the severity of the constraint. According to the Association of Organ Procurement Organizations, in 2025, over 104,000 patients are on the national waiting list for lifesaving transplants. This statistic underscores the disconnect between clinical need and resource availability, as the number of candidates far exceeds the donor pool. As a result, the potential revenue for preservation manufacturers is restricted, preventing the market from realizing the full scope of demand indicated by the global burden of chronic diseases.

Key Market Trends

The emergence of organ care service and outsourcing models is reshaping the market by shifting the focus from capital equipment ownership to comprehensive logistical support. Hospitals and transplant centers are increasingly relying on turnkey service networks that manage the entire organ retrieval, perfusion, and transport process, thereby reducing the operational burden on surgical teams. This business model innovation allows institutions to access advanced perfusion capabilities without significant upfront investment in hardware or specialized staffing. According to Medical Buyer, October 2025, in the 'TransMedics Group revenue up 32% to USD 143.8M in Q3 2025', the company reported a 32 percent increase in quarterly revenue, a growth trajectory primarily driven by the expanding utilization of its National OCS Program (NOP) logistics and clinical service network rather than direct console sales alone.

The development of portable and automated organ transport systems is simultaneously revolutionizing donor organ mobility and post-transplant survival rates. Unlike improved static cold storage, these sophisticated automated devices actively monitor and regulate the organ's environment during transit, offering a level of protection that significantly mitigates long-term clinical risks. The integration of continuous monitoring and temperature control within a portable form factor is delivering measurable improvements in patient longevity. According to the Organ Donation Alliance, June 2025, in the 'New Study Reports Increased 4-Year Survival in Heart Transplant Patients when Utilizing the Paragonix SherpaPak System', data from the GUARDIAN-Heart Registry revealed that hearts preserved using this automated technology demonstrated a 54 percent reduction in four-year mortality rates compared to those transported via traditional ice storage methods.

Segmental Insights

The University of Wisconsin Solution segment represents the fastest-growing category in the global organ preservation market due to its extensive clinical utility for multi-organ preservation. This intracellular formulation is widely utilized for the static cold storage of liver, kidney, and pancreas allografts because it effectively mitigates cellular swelling and extends safe preservation windows. The sustained demand is further bolstered by established approvals from major regulatory authorities, such as the U.S. Food and Drug Administration, which validate its safety profile. Consequently, transplant centers prioritize this solution to ensure optimal organ viability during complex logistical processes.

Regional Insights

North America maintains a leading position in the global organ preservation market, driven by established healthcare infrastructure and a high volume of transplant procedures. The regional dominance is supported by favorable reimbursement policies and the concentration of key market players. Additionally, regulatory bodies like the U.S. Food and Drug Administration (FDA) provide structured approval pathways for preservation devices and solutions. The efficient coordination of donors and recipients by the United Network for Organ Sharing (UNOS) further stabilizes demand, ensuring the continuous adoption of preservation technologies across the healthcare sector.

Recent Developments

• In August 2025, TransMedics Group, Inc. announced that it received conditional approval from the U.S. Food and Drug Administration for its Investigational Device Exemption to commence the Next-Generation OCS ENHANCE Heart trial. This regulatory milestone enables the company to initiate a large-scale study designed to evaluate the clinical superiority of its proprietary warm perfusion platform over standard static cold storage for hearts donated after brain death. The trial is expected to be a significant research undertaking in the field, potentially reshaping preservation standards and increasing the utilization of donor hearts for patients with end-stage heart failure.
• In December 2024, Bridge to Life Ltd. completed the acquisition of the VitaSmart Hypothermic Oxygenated Machine Perfusion System from Medica S.p.A., securing exclusive global trademark and commercialization rights. The President of Bridge to Life Ltd. noted that the system has already supported over 5,000 liver perfusions worldwide utilizing Hypothermic Oxygenated Perfusion protocols. This strategic transaction enhances the company's asset portfolio and prepares the organization for a planned FDA submission in early 2025. The acquisition is intended to accelerate the availability of this advanced perfusion technology to transplant centers and organ procurement organizations across the United States.
• In November 2024, OrganOx Ltd. entered into an exclusive clinical co-development agreement with a biotechnology firm to advance a novel liver support system for acute liver failure. This collaboration integrates the company's normothermic machine perfusion technology with genetically engineered porcine livers to create an external support device for patients with decompensated livers. The partnership targets a critical unmet need for approximately 35,000 patients hospitalized annually in the United States. By combining these distinct technologies, the companies aim to provide a therapeutic bridge that allows the patient's native liver to recover or sustains them until a transplant becomes available.
• In June 2024, Paragonix Technologies launched the PancreasPak Organ Preservation System, establishing it as the first FDA-cleared device designed specifically to protect and monitor donor pancreases during transportation. The Chief Executive Officer of Paragonix Technologies stated that this innovation addresses a significant lack of specialized technology in the pancreatic market, utilizing proven thermal control methods to maintain organs between 4-8°C. This product launch represents a strategic expansion of the company’s portfolio, aiming to improve organ function and transplant outcomes for patients by replacing traditional ice-storage methods with advanced, controlled preservation environments.

Key Market Players

• Paragonix Technologies, Inc
• XVIVO Perfusion AB
• Dr. Franz Köhler Chemie GmbH
• OrganOx Limited
• Bridge to Life (Europe) Ltd.
• Waters Medical Systems, LLC
• Preservation Solutions Inc.
• Artivion, Inc
• Vascular Perfusion Solutions, Inc
• Global Transplant Solutions

By Solution	By Technique	By Organ Type	By End User	By Region
University of Wisconsin Solution (UW Solution) Custodial HTK Perfadex Other Solutions	Static Cold Storage Hypothermic Machine Perfusion Normothermic Machine Perfusion	Kidney Liver Lung Heart Pancreas	Organ Transplant Centers Hospitals Specialty Clinics	North America Europe Asia Pacific South America Middle East & Africa

Report Scope:

In this report, the Global Organ Preservation Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

• Organ Preservation Market, By Solution:

• University of Wisconsin Solution (UW Solution)
• Custodial HTK
• Perfadex
• Other Solutions

• Organ Preservation Market, By Technique:

• Static Cold Storage
• Hypothermic Machine Perfusion
• Normothermic Machine Perfusion

• Organ Preservation Market, By Organ Type:

• Kidney
• Liver
• Lung
• Heart
• Pancreas

• Organ Preservation Market, By End User:

• Organ Transplant Centers
• Hospitals
• Specialty Clinics

• Organ Preservation Market, By Region:

• North America
• United States
• Canada
• Mexico
• Europe
• France
• United Kingdom
• Italy
• Germany
• Spain
• Asia Pacific
• China
• India
• Japan
• Australia
• South Korea
• South America
• Brazil
• Argentina
• Colombia
• Middle East & Africa
• South Africa
• Saudi Arabia
• UAE