Next Generation Sequencing (NGS) Library Preparation Automation Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Product (Kits and Consumables v/s Instruments), By Sequencing Type (DNA Sequencing v/s RNA Sequencing), By Application (Diagnostics v/s Scientific Research), By End User (Pharmaceutical & Biotechnology Companies, Clinical & Diagnostic Laboratories, Academic & Research Institutions, Others), By Company and By Region 2020-2030F

Market Overview

The Global Next Generation Sequencing (NGS) Library Preparation Automation Market was valued at USD 700.22 Million in 2024 and is expected to reach USD 1051.41 Million by 2030 with a CAGR of 6.97% during the forecast period. Next-Generation Sequencing (NGS) library preparation automation refers to the use of advanced robotic and automated platforms to streamline the preparation of DNA or RNA libraries before sequencing. Library preparation involves processes such as fragmentation, adapter ligation, amplification, and quality control, which are traditionally labor-intensive and susceptible to human error. Automation enhances these workflows by increasing precision, reducing variability, and enabling laboratories to process large sample volumes with greater efficiency and consistency. According to a study published in ScienceDirect in April 2024, the adoption of next-generation sequencing (NGS) increased significantly across various tumor types, rising from 0.0%–1.5% in 2015 to 2.1%–17.4% in 2021. Among these, metastatic non–small-cell lung cancer recorded the highest NGS utilization, while metastatic breast cancer reported the lowest in 2021. The variation in NGS adoption rates across tumor types may be attributed, in part, to differences in guideline recommendations.

The competitive landscape is shaped by leading companies including Illumina, Agilent Technologies, Thermo Fisher Scientific, Roche, and QIAGEN. These players are focusing on innovation, strategic collaborations, and mergers to strengthen their market presence. Despite high equipment costs and the requirement for specialized technical expertise, opportunities exist in the development of more affordable, user-friendly automation solutions for smaller laboratories.

The increasing demand for advanced applications such as RNA sequencing and single-cell sequencing will create new avenues for growth. Overall, the NGS library preparation automation market is positioned for significant expansion, driven by technological advancements, rising clinical adoption, and the growing importance of genomics in precision medicine.

Key Market Drivers

Rising Emphasis on Precision Medicine

The global next-generation sequencing (NGS) library preparation automation market is witnessing robust growth, largely fueled by the rising emphasis on precision medicine. Precision medicine, which tailors healthcare solutions based on individual genetic profiles, requires large-scale genomic data analysis to identify biomarkers, disease predispositions, and treatment responses. NGS has become the cornerstone of this approach, enabling rapid, accurate, and cost-effective sequencing. Automated library preparation systems play a critical role in ensuring scalability, reproducibility, and efficiency, making them indispensable for advancing precision medicine initiatives.

As demand for personalized therapies increases, healthcare systems and research institutions are rapidly adopting automated solutions to manage the complexity and volume of genomic data. Automated NGS library preparation not only reduces hands-on time and labor costs but also minimizes errors, leading to higher-quality data for clinical decision-making. These advantages are particularly relevant for oncology, rare disease research, and pharmacogenomics, where precision medicine is being actively implemented. Moreover, government investments and public-private partnerships in precision medicine programs are accelerating the adoption of NGS automation technologies. Pharmaceutical companies are also leveraging automated platforms to streamline biomarker discovery and companion diagnostics development, further driving market expansion. With the ongoing integration of artificial intelligence and robotics, NGS library preparation automation is expected to become even more efficient, positioning itself as a vital enabler of the precision medicine revolution.

The growing prioritization of precision medicine across healthcare and life sciences is creating strong momentum in the global NGS library preparation automation market. Companies that provide innovative, scalable, and user-friendly automation solutions stand to benefit significantly as precision medicine continues to reshape clinical research and patient care.

Government Initiatives and Research Funding

Government initiatives and targeted research funding have become a principal catalyst for growth in the global next-generation sequencing (NGS) library preparation automation market. National genomic strategies and high-value public investments are expanding demand for high-throughput, reproducible workflows: when governments commit to large sequencing programmes or newborn/genomic screening efforts, laboratories face immediate pressure to scale up sample throughput while maintaining quality and regulatory compliance — conditions that favor automated library-preparation platforms over manual processes.  In 2022, total biotechnology financing by the National Institutes for Health was USD7,912 billion.

Large national programmes act as demand multipliers. Examples such as the UK’s genomic initiatives — including multi-year funding and plans to offer whole-genome sequencing at population scale — create predictable, long-term procurement needs for instruments, consumables and integrated automation solutions. These programmes not only purchase systems directly but also finance associated infrastructure (biobanks, data pipelines, quality frameworks) that lowers the barrier for laboratories to adopt end-to-end automated NGS workflows. The result is more rapid procurement cycles and larger unit volumes for library-prep automation vendors.  For instance, in 2020, the FDA’s Center for Drug Evaluation and Research (CDER) certified 53 novel drugs, whereas 48 were approved in 2019. In the U.S, the revenue in scientific R&D is likely to amount to USD 8.11 billion by the end of 2022. 

Public research grants and investigator support broaden the market by underwriting method development and throughput trials that validate automation. Funding initiatives aimed at early-career researchers and translational science (for example, national grant programmes that prioritize high-impact genomics and automation-friendly protocols) accelerate adoption at academic core facilities and translational labs. These grants commonly include budget lines for equipment and service contracts, enabling smaller research groups to leverage robotic library-preparation platforms and thereby mainstream automation across diverse research applications.

Supranational and regional funding mechanisms — notably Horizon Europe and similar health-cluster work programmes — are also shifting the market toward automation by financing multi-centre projects that require standardized, reproducible sample processing across sites. When cross-border research consortia receive grants that mandate harmonized protocols, centralized purchasing and validated automated workflows become attractive solutions for ensuring data comparability and regulatory traceability across participating laboratories. This trend supports vendors that offer scalable, interoperable automation systems and consortium-level service models.

Industrial policy and state investment in domestic genomics capacity further strengthen the business case for automation. State-backed investments in national sequencing centres — such as significant credit lines, subsidies or direct capital injections to build sequencing capacity — create regional hubs that demand industrialized sample-preparation pipelines. Public investment in large sequencing outfits and national gene banks can rapidly drive purchases of automated library-prep platforms and associated consumables, while also encouraging local service ecosystems (training, maintenance, reagent supply) that support long-term market expansion.

The combined effect for market structure is material: predictable, government-sponsored sequencing volumes reduce price sensitivity and raise willingness to invest in higher-upfront capital (robots, integrated workstations) because total cost-of-ownership falls with scale and reduced labor burden. Automation vendors that align their value propositions to public-sector procurement priorities — reproducibility, regulatory compliance, standardized kits and validated workflows — capture larger, longer-duration contracts. The public funding environment also encourages innovation: research grants underwrite method validation and pilot implementations that become commercial reference cases, shortening sales cycles to other institutions and accelerating overall market adoption.

Government initiatives and research funding are not merely supporting the science of genomics — they are actively reshaping the NGS library-preparation landscape by creating large, durable pools of demand, funding infrastructure and de-risking capital investments in automation. For suppliers and investors, the imperative is clear: design offerings and commercial strategies that meet public-sector requirements (scalability, compliance, total-cost transparency) and partner closely with funded programmes to convert public genomics ambitions into sustained market growth.

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Key Market Challenges

High Capital and Operational Costs

One of the primary barriers to the adoption of automated NGS library preparation systems is their substantial initial investment and ongoing operational costs. Automated instruments can range from $45,000 to $300,000, depending on throughput capabilities, which may be prohibitive for smaller laboratories or institutions with limited budgets. Additionally, the costs associated with consumables, maintenance, and training further contribute to the financial burden, potentially deterring adoption among cost-sensitive entities.

Key Market Trends

Technological Advancements

The global Next-Generation Sequencing (NGS) library preparation automation market is experiencing robust growth, primarily fueled by rapid technological advancements. Innovations in automated systems have significantly enhanced the efficiency, accuracy, and throughput of NGS library preparation, which is critical for genomic research, clinical diagnostics, and personalized medicine. Advanced robotics, microfluidic technologies, and AI-driven platforms are streamlining workflows, reducing manual intervention, and minimizing human error, thereby accelerating the adoption of automated NGS solutions across research and clinical laboratories.

Technological progress has also enabled the development of high-throughput automation platforms capable of processing large sample volumes with consistent quality. Integration of novel liquid handling systems, miniaturized reaction volumes, and automated quality control measures ensures reproducibility and reliability, addressing long-standing challenges associated with manual library preparation. These innovations are particularly crucial for applications in oncology, rare disease research, and infectious disease monitoring, where precision and speed are paramount.

Continuous advancements in software and bioinformatics tools are complementing hardware improvements by providing seamless data management, workflow optimization, and error tracking. This integration allows laboratories to handle increasingly complex NGS assays efficiently, reducing turnaround times and operational costs. As a result, both established research institutions and emerging biotech companies are investing heavily in automated NGS library preparation platforms to maintain a competitive edge in the rapidly evolving genomics landscape. The convergence of cutting-edge automation technologies, miniaturization, and intelligent software solutions is reshaping the NGS library preparation landscape. The ongoing technological evolution not only enhances operational efficiency but also expands the scope of genomic research and clinical applications, positioning the global NGS library preparation automation market for sustained growth in the coming years.

Segmental Insights

Product Insights

Based on the Product, the Kits and Consumables segment has emerged as the fastest-growing segment in the Global Next Generation Sequencing (NGS) Library Preparation Automation Market in 2024, due to the increasing demand for standardized, ready-to-use solutions that simplify the complex workflow of NGS library preparation. These products ensure consistency, reproducibility, and accuracy across high throughput sequencing experiments, making them essential for both research and clinical applications. Moreover, the rising adoption of NGS in oncology, infectious disease testing, and personalized medicine has amplified the need for reliable kits and consumables to support routine sequencing operations. Since they are required on a recurring basis, unlike instruments, this segment benefits from a continuous revenue stream, driving its accelerated growth in 2024.

Sequencing Type Insights

Based on Sequencing Type, the DNA Sequencing segment has emerged as the fastest-growing segment in the Global Next Generation Sequencing (NGS) Library Preparation Automation Market in 2024, due to its widespread applications across healthcare, research, and diagnostics. DNA sequencing is increasingly adopted for precision medicine, oncology, genetic testing, and infectious disease surveillance, where rapid and accurate genomic insights are critical. The growing demand for large-scale sequencing in population genomics projects, coupled with advancements in automation technologies that reduce errors, costs, and turnaround time, has further accelerated adoption. Additionally, pharmaceutical and biotech companies are leveraging DNA sequencing to streamline drug discovery and biomarker development, strengthening its dominance within the market.

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Regional Insights

North America has emerged as the largest region in the Global Next Generation Sequencing (NGS) Library Preparation Automation Market in 2024, due to its strong presence of advanced healthcare infrastructure, significant investment in genomics research, and high adoption of cutting-edge sequencing technologies. The region benefits from substantial government and private funding that accelerates innovation in genomic medicine, precision healthcare, and oncology diagnostics. Additionally, the presence of major market players, established academic institutions, and biotechnology firms drives continuous development and adoption of automated solutions. Favorable regulatory frameworks, coupled with the growing demand for personalized medicine, further strengthen North America’s dominant position in this market.

Recent Development

In April 2025, Cepheid and Oxford Nanopore Technologies announced a strategic collaboration to advance automated sequencing-based solutions. The partnership integrates Cepheid’s GeneXpert system for pre-sequencing sample processing and library preparation with Oxford Nanopore’s rapid, high-resolution molecular analysis platform. A successful proof-of-concept demonstrated the feasibility of combining these technologies, establishing the foundation for a joint Research Use Only (RUO) workflow. This workflow enables rapid, in-house sequencing for infectious disease analysis, delivering results within hours. Initially targeting the profiling of bacterial and fungal pathogens from culture isolates, the collaboration is expected to expand into broader infectious disease applications and, ultimately, into regulatory-approved clinical diagnostics.

In February 2025, seqWell introduced early access to its MosaiX Library Prep Kit, designed for human population genomics applications including whole genome sequencing (WGS) and whole exome sequencing. The kit incorporates seqWell’s TnX transposase, delivering enhanced activity with reduced insertion-site bias. It provides a streamlined 90-minute end-to-end workflow, generating PCR-ready libraries in as little as 45 minutes.

In January 2025, Thermo Fisher Scientific introduced Olink Reveal, an innovative next-generation sequencing (NGS)-based proteomics solution designed for seamless integration with existing NGS platforms, including Illumina’s NextSeq 2000, NovaSeq X, and NovaSeq 6000. Olink Reveal enables researchers to measure approximately 1,000 human proteins, supporting both broad proteome screening and detailed characterization of critical inflammatory processes.

In October 2024, BD (Becton, Dickinson, and Company) launched a robotics-compatible reagent kit designed to automate and standardize single-cell research workflows. Developed in collaboration with Hamilton Company, the solution integrates BD’s OMICS-One XT WTA Assay with Hamilton’s Microlab NGS STAR automated liquid handling platform to streamline DNA library preparation, a critical step in single-cell multiomics research. This integration enables high-throughput processing, minimizes manual errors, and enhances reproducibility, particularly in oncology and immunology applications. The commercially available solution offers researchers a scalable, efficient approach to single-cell analysis, supporting the growing demand for advanced multiomics research.

Key Market Players

• Agilent Technologies, Inc.
• BGI Group
• Aurora Biomed Inc.
• Bio-Rad Laboratories, Inc.
• Danaher Corporation
• F.Hoffmann-La Roche AG
• Eppendorf SE
• Hamilton Company
• Hologic Inc.
• Illumina Inc.
• Oxford Nanopore Technologies Limited
• PerkinElmer, Inc.
• Promega Corporation
• Takara Bio Inc.
• QIAGEN NV

Report Scope

In this report, global next generation sequencing (NGS) library preparation automation market has been segmented into following categories, in addition to the industry trends which have also been detailed below:

·         Next Generation Sequencing (NGS) Library Preparation Automation Market, By Product:

• Kits and Consumables
• Instruments    

·         Next Generation Sequencing (NGS) Library Preparation Automation Market, By Sequencing Type:

• DNA Sequencing
• RNA Sequencing

·         Next Generation Sequencing (NGS) Library Preparation Automation Market, By Application:

• Diagnostics
• Scientific Research

·         Next Generation Sequencing (NGS) Library Preparation Automation Market, By End User:

• Pharmaceutical & Biotechnology Companies
• Clinical & Diagnostic Laboratories
• Academic & Research Institutions
• Others

·         Next Generation Sequencing (NGS) Library Preparation Automation Market, By Region:

• North America
• United States
• Canada
• Mexico
• Asia-Pacific
• China
• India
• Japan
• Australia
• South Korea
• Europe & CIS
• Germany
• France
• United Kingdom
• Spain
• Italy
• South America
• Brazil
• Argentina
• Colombia
• Middle East & Africa

o   South Africa

o   Saudi Arabia

o   UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in global next generation sequencing (NGS) library preparation automation Market

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Company Information

• Detailed analysis and profiling of additional market players (up to five).