Europe Synthetic Hormones Market By Product Type (Steroid Hormones, Peptide Hormones, and Others), By Route of Administration (Subcutaneous, Oral, Intravenous/Intramuscular, and Others), By Application (Diabetes, Growth Hormone Deficiency, Contraception, Male Hypogonadism, Menopause, and Others), By End User (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), By Country, Competition, Forecast and Opportunities, 2020-2030F

Market Overview

Europe Synthetic Hormones Market was valued at USD 5.26 Billion in 2024 and is expected to reach USD 8.24 Billion by 2030 with a CAGR of 7.73% during the forecast period. The Europe Synthetic Hormones Market is primarily driven by the increasing prevalence of hormonal disorders such as hypothyroidism, menopause, and infertility, which require synthetic hormone therapies for effective management. The aging population across Europe also contributes significantly, as older adults are more likely to experience hormonal imbalances, particularly during menopause or as part of thyroid dysfunctions. Advancements in hormone therapy, including improved formulations and delivery methods, have enhanced the effectiveness and safety of synthetic hormones, further driving market demand. The rising focus on women's health, particularly for fertility treatments and hormone replacement therapies (HRT), is contributing to market growth. Regulatory support, especially in countries like Germany and the UK, is enabling easier access to these therapies, while increasing awareness about hormonal health is encouraging more patients to seek treatment, thus further expanding the synthetic hormones market across Europe.

Key Market Drivers

Aging Population

The aging population in Europe is one of the primary drivers of the synthetic hormones market, contributing to increased demand for various hormonal therapies, including hormone replacement therapy (HRT) and thyroid hormone management. As people age, hormonal imbalances become more prevalent due to the natural decline in hormone production. As of January 1, 2023, the population of the EU was estimated at 448.8 million, with over one-fifth (21.3%) of this population being 65 years or older. The median age of the EU population reached 44.5 years, meaning half of the population was older than this age, while the other half was younger. From 2013 to 2023, the median age increased in all EU countries, with the exceptions of Malta and Sweden, where it decreased slightly by -0.4 and -0.1 years, respectively, and Germany, where the median age remained stable.

In particular, for women undergoing menopause, the reduction in estrogen and progesterone levels triggers symptoms such as hot flashes, mood swings, and bone loss, necessitating the use of synthetic hormones for symptom management. The use of synthetic hormones such as estrogen, progesterone, and testosterone helps restore hormonal balance and alleviate these symptoms, improving the quality of life for aging individuals. Older adults, both men and women, are more prone to thyroid disorders such as hypothyroidism and hyperthyroidism, both of which require synthetic hormone treatments for effective management. Given the growing number of elderly individuals in Europe, the demand for hormone therapies is increasing as these conditions become more prevalent with age. According to recent demographic trends, Europe’s aging population is expected to continue to expand, creating a long-term need for synthetic hormones to treat age-related hormonal imbalances. This demographic shift is creating a sustained demand for synthetic hormone products, especially as Europe’s healthcare systems evolve to address the needs of aging individuals.

Rising Prevalence of Hormonal Disorders

The increasing incidence of hormonal disorders in Europe is another significant factor driving the demand for synthetic hormones. Disorders such as hypothyroidism, hyperthyroidism, polycystic ovary syndrome (PCOS), and infertility have become more common, leading to a higher need for hormone-based treatments. According to a study ttiled, “The Burden of Hormonal Disorders: A Worldwide Overview With a Particular Look in Italy”, according to data from the European Observatory of Health Policies and Systems, cardiovascular diseases are the leading causes of mortality in Italy, affecting 40% of women and 35% of men, followed by oncological diseases, which account for 24% of deaths in women and 33% in men. Endocrine diseases rank fifth on the list, contributing to 5% of deaths in women and 4% in men, following respiratory diseases (6% in women and 8% in men) and neurological diseases (8% in women and 5% in men). The prevalence of endocrine disorders is approximately 45 cases per 100,000 individuals, with an annual incidence rate of 4 cases per 100,000 inhabitants.

Thyroid dysfunctions, in particular, are rising at an alarming rate in Europe, with conditions like hypothyroidism requiring synthetic thyroid hormones (e.g., levothyroxine) for patients to restore normal thyroid function. Likewise, women with PCOS face hormonal imbalances involving elevated levels of androgens and disrupted ovarian function, often requiring synthetic hormones to manage symptoms such as irregular periods and excessive hair growth. As infertility rates rise due to lifestyle factors and delayed pregnancies, synthetic hormones play an essential role in fertility treatments. For instance, gonadotropins and estrogen are widely used to stimulate ovulation and support in vitro fertilization (IVF) treatments. The rising awareness around these conditions, coupled with improvements in diagnostic methods, is leading to earlier diagnoses and a growing number of patients seeking synthetic hormone treatments. This trend underscores the growing demand for synthetic hormones to restore hormonal equilibrium and manage a variety of health conditions, making it a key driver for the market.

Strong Pharmaceutical Industry in Europe

Europe boasts a strong pharmaceutical industry with leading companies that are heavily invested in the research, development, and commercialization of synthetic hormone products. Global pharmaceutical giants, along with innovative biotech companies, play a crucial role in driving market growth. The European pharmaceutical sector has the resources, expertise, and infrastructure necessary to bring new hormone therapies to market, ensuring that patients have access to the latest treatments. The industry is well-established in key European markets like Germany, France, and the UK, where large pharmaceutical companies are actively developing and testing hormone-based therapies. This robust industry support continues to contribute significantly to the overall growth and expansion of the synthetic hormones market across Europe.

Increased Awareness of Hormonal Health

Increased awareness of hormonal health has become a significant driver of the synthetic hormones market in Europe. Public health campaigns, patient education initiatives, and widespread access to health information have led to a growing recognition of the role hormones play in overall well-being. People are becoming more aware of how hormonal imbalances can affect physical and emotional health, leading to a surge in demand for treatments such as synthetic hormones to address issues like menopause, PCOS, thyroid disorders, and fertility issues. The increasing awareness of these conditions and the availability of effective treatment options has empowered patients to seek medical help earlier, resulting in earlier diagnoses and interventions. As individuals recognize the importance of maintaining hormonal balance to prevent or manage health conditions, the demand for synthetic hormone therapies is expected to grow. Social media, online platforms, and medical professionals are contributing to the dissemination of information related to hormonal health, encouraging individuals to pursue appropriate treatments. This rising awareness among the population is translating into an expanding market for synthetic hormones in Europe.

Growth in Female Health Focus

The growing focus on female health is another key driver of the synthetic hormones market in Europe. Women’s health issues such as menopause, osteoporosis, and fertility disorders have become a priority, and synthetic hormones play a critical role in addressing these concerns. Hormone replacement therapy (HRT) is commonly prescribed to manage menopause symptoms, and with a larger aging female population in Europe, the demand for these treatments is increasing. Similarly, synthetic hormones are widely used in fertility treatments, particularly for in vitro fertilization (IVF) and ovulation induction. According to a report titled, “Care reality of menopausal women in Germany: healthcare research using quantitative (SHI claims data) and qualitative (survey) data collection”, Hormone replacement therapy (HRT) is considered the most effective treatment for alleviating symptoms such as hot flashes, improving sleep quality, and reducing the severity of depression. To better understand the healthcare needs and disease burden of menopausal women, a survey was conducted with 1,000 women aged 45–60 years, covering topics like quality of life, menopause, and HRT. Additionally, a quantitative, longitudinal healthcare study was carried out using anonymized, age- and sex-adjusted routine data from Statutory Health Insurance (SHI), which includes approximately four million insured individuals annually. Among over half a million women aged 35–70 years with statutory health insurance (n = 613,104), 14% (n = 82,785) were diagnosed with climacteric disorder in 2014. Of these women, 21% were prescribed HRT on an outpatient basis. According to a Forsa survey, 50% of the women reported feeling moderately to very poorly informed about treatment options.

The growing focus on female health, including addressing issues such as endometriosis, fibroids, and irregular periods, has contributed to increased recognition of the importance of hormonal therapy. As more attention is paid to women’s health, both by healthcare providers and policymakers, the demand for effective synthetic hormone therapies will continue to grow. The broader focus on women’s health has also sparked innovation in the development of new hormone treatments and personalized care options that will further stimulate market growth.

Rising Demand for Fertility Treatments

The rising demand for fertility treatments in Europe is a significant driver of the synthetic hormones market. Factors such as delayed pregnancies, changing lifestyles, and increasing rates of infertility have contributed to a growing need for assisted reproductive technologies (ART) like in vitro fertilization (IVF). In 2022, there were 3.88 million births in the European Union, resulting in a crude birth rate of 8.7 live births per 1,000 people. For comparison, the EU's crude birth rate was 10.5 in 2000, 12.8 in 1985, and 16.4 in 1970. Between 1961 and 2022, the highest annual number of live births in the EU occurred in 1964, with 6.8 million children born. Following this peak, the number of live births steadily declined until the early 21st century, reaching a low of 4.36 million in 2002. Afterward, there was a modest recovery, with the number of live births rising to 4.68 million in 2008. This was followed by a general downward trend, though there were slight increases in 2014 and 2016. During the COVID-19 pandemic, the number of live births first dropped to 4.07 million in 2020, slightly increased to 4.09 million in 2021, and then decreased again to 3.88 million in 2022. Synthetic hormones, including gonadotropins, estrogen, and progesterone, are essential components of fertility treatments, as they stimulate ovulation, prepare the uterus for embryo implantation, and support early pregnancy. The increasing acceptance and availability of fertility treatments in Europe are further boosting the market for synthetic hormones. Advancements in ART procedures, such as genetic screening and improved embryo culture media, are making fertility treatments more successful, leading to higher demand for hormone therapies. As more individuals and couples turn to fertility treatments to achieve parenthood, the synthetic hormones market is expected to see continued growth in this segment.

Download Free Sample Report

Key Market Challenges

Safety Concerns and Side Effects

Despite the effectiveness of synthetic hormone therapies, safety concerns and potential side effects remain significant challenges that impact the growth of the synthetic hormones market in Europe. While synthetic hormones are widely used for managing conditions such as menopause, thyroid dysfunction, and infertility, their long-term use can lead to various health risks. For example, hormone replacement therapy (HRT), a common treatment for menopausal symptoms, has been associated with an increased risk of developing breast cancer, blood clots, and stroke. These potential side effects, especially in the case of prolonged hormone therapy, have led to concerns among healthcare providers and patients alike.

The ongoing debate about the safety of HRT and other synthetic hormone therapies often results in hesitancy from patients and physicians, thus slowing market adoption. In addition, the risks associated with synthetic hormones have prompted regulatory bodies, such as the European Medicines Agency (EMA), to issue guidelines and warnings about the proper use of certain hormone therapies. These safety concerns can limit the widespread acceptance of synthetic hormones, particularly for long-term treatment, and may discourage some patients from considering hormone therapy as an option.

Despite advancements in hormone formulations, such as the development of bioidentical hormones, which are chemically identical to naturally occurring hormones, concerns about adverse effects remain. Patients and healthcare providers often prefer more natural alternatives or seek more personalized approaches to hormone therapy to reduce side effects. This trend towards natural and bioidentical hormone treatments also presents a competitive challenge for synthetic hormone manufacturers, who must continually improve their products to address these safety concerns and enhance their market appeal.

To overcome this challenge, further research and development efforts are needed to create synthetic hormone treatments with fewer side effects, better patient tolerability, and more personalized approaches to care. Patient education and transparent communication about the risks and benefits of synthetic hormones will be crucial in alleviating concerns and improving adherence to prescribed therapies.

Regulatory Hurdles

The regulatory landscape in Europe can be a significant challenge for companies operating in the synthetic hormones market. The process of obtaining regulatory approval for new hormone treatments can be lengthy, expensive, and complex, as synthetic hormone products must meet rigorous safety and efficacy standards set by regulatory bodies like the European Medicines Agency (EMA) and national health authorities. This regulatory burden slows down the time to market for new products and can deter smaller companies or new entrants from entering the market.

The approval process for synthetic hormones often involves multiple stages of clinical trials, including preclinical testing, human clinical trials, and post-market surveillance, all of which incur substantial costs. Companies must demonstrate the safety, effectiveness, and quality of their products through comprehensive scientific evidence, which can be a resource-intensive process. Each European country may have its own set of regulatory requirements, further complicating market entry and expansion efforts. Different regulatory standards for packaging, labeling, and patient information across the continent can add significant complexity for manufacturers who aim to sell their products in multiple countries within Europe.

Changing regulations or the introduction of new guidelines could require companies to modify existing products or adjust their marketing strategies. For example, the increasing scrutiny over hormone therapies due to their potential risks has led to stricter regulations on how these products are marketed and prescribed. These changes in regulatory frameworks could limit the availability of certain hormone therapies or affect their market uptake, thus creating challenges for companies in terms of compliance, product launches, and ongoing market access.

In addition to regulatory challenges, European countries also have national healthcare reimbursement policies that vary significantly, influencing the affordability and accessibility of synthetic hormone treatments. Governments may impose restrictions on the reimbursement of hormone therapies, which could limit patient access and reduce the demand for these treatments. Regulatory hurdles can thus affect the cost structure, pricing, and market reach for synthetic hormone products in Europe. To address these challenges, companies must navigate the regulatory landscape with careful planning, investing in regulatory affairs teams and resources to ensure compliance. Continuous engagement with regulatory bodies and policymakers can help companies stay informed about regulatory changes and adapt their strategies accordingly.

Key Market Trends

Advancements in Hormone Therapy

Advancements in hormone therapy have played a vital role in driving the growth of the synthetic hormones market in Europe. Over the years, technological innovations have led to the development of safer and more effective hormone treatments, which has enhanced the accessibility and acceptability of these therapies. One such advancement is the introduction of bioidentical hormones, which are chemically identical to those naturally produced by the body. These hormones have gained popularity, especially in hormone replacement therapy (HRT) for menopause, due to their perceived safety and reduced risk of side effects. New delivery methods, including patches, gels, and implants, have improved patient compliance and convenience, as these treatments are easier to administer and offer more consistent dosing compared to traditional oral tablets. Advancements in formulations and drug efficacy have led to more targeted and personalized treatments, reducing the potential for adverse effects. As these innovations continue to evolve, synthetic hormones are becoming more effective and appealing to both patients and healthcare providers, fueling market growth. These advancements are supported by an increase in clinical trials and research focused on improving hormone therapies, which will contribute to an expanding portfolio of products that cater to a diverse range of hormonal imbalances and conditions.

Expanding Applications of Synthetic Hormones

The expanding applications of synthetic hormones are also fueling the growth of the market. Beyond traditional uses like hormone replacement therapy (HRT) and fertility treatments, synthetic hormones are being explored for the management of other conditions such as obesity, depression, metabolic disorders, and cardiovascular disease. As research into the broader therapeutic applications of synthetic hormones progresses, new treatments are emerging, which could significantly expand the market. For instance, synthetic hormones may be used to regulate insulin resistance or manage adrenal insufficiency, further broadening their clinical use. The expanding range of conditions that can be treated with synthetic hormones will drive demand for these therapies, presenting new growth opportunities for the market.

Segmental Insights

Product Type Insights

Based on the product type, steroid hormones are currently dominating the market, owing to their widespread use in treating a variety of conditions such as menopause, thyroid disorders, infertility, and various other endocrine-related issues. Steroid hormones, which include estrogen, progesterone, testosterone, and corticosteroids, have been the cornerstone of hormone replacement therapies (HRT) for decades. These hormones are chemically synthesized to mimic the naturally occurring hormones in the body, providing essential therapeutic benefits to patients suffering from hormonal imbalances.

One of the primary drivers for the dominance of steroid hormones in the European market is the high prevalence of menopause among women, particularly as the population continues to age. Hormone replacement therapy (HRT) using synthetic estrogen and progesterone remains the go-to treatment for alleviating symptoms such as hot flashes, night sweats, and mood swings that accompany menopause. Similarly, testosterone replacement therapy is commonly prescribed for managing symptoms of male hypogonadism and age-related testosterone decline. The effectiveness and established clinical track record of steroid hormone therapies make them a preferred option for both patients and healthcare providers.

Application Insights

Based on the application, menopause is currently the dominant driver of the synthetic hormones market. The widespread use of hormone replacement therapy (HRT) for managing menopausal symptoms has positioned menopause as the leading condition for synthetic hormone therapies in Europe. As the population ages, particularly the baby boomer generation, the incidence of menopause and related symptoms continues to rise, leading to an increased demand for synthetic estrogen and progesterone treatments to alleviate hot flashes, night sweats, mood swings, and other discomforts associated with this phase of life. HRT remains a cornerstone of menopausal care, making it the most significant application in the synthetic hormones market.

The rise in the aging population, particularly women aged 45-55 years, is a primary driver for this trend. In Europe, menopause affects a substantial portion of the population, and as women live longer, the number of women seeking relief from menopausal symptoms has surged. Synthetic estrogen and progesterone are commonly used in combination to provide effective symptom relief and reduce the risks associated with osteoporosis and cardiovascular diseases, which become more pronounced after menopause. The clinical success and long history of hormone replacement therapies for menopause have reinforced their dominance in the synthetic hormones market.  Menopause-related conditions such as osteoporosis and vaginal atrophy also contribute to the demand for synthetic hormone treatments. Estrogen, particularly, is known to help prevent bone loss and maintain bone density, a critical concern for menopausal women who are at higher risk of fractures and osteoporosis. This has further driven the need for hormone replacement therapy, with both oral and transdermal forms of estrogen seeing strong demand in the European market.

Download Free Sample Report

Country Insights

Germany was the dominant region in the synthetic hormones market. The country’s leading position can be attributed to several key factors, including its robust healthcare infrastructure, high awareness levels regarding hormone therapies, and a well-established pharmaceutical sector. As the largest economy in Europe, Germany also has the resources and market access to support a highly efficient healthcare system that drives demand for various therapeutic treatments, including synthetic hormones.

One of the primary drivers for Germany’s dominance in the synthetic hormones market is its aging population. With a significant proportion of the population aged 50 and above, there is a growing demand for hormone replacement therapies (HRT), particularly among women undergoing menopause. Synthetic hormones, such as estrogen and progesterone, are commonly used to alleviate symptoms associated with menopause, and Germany, with its well-established healthcare system, has a high rate of HRT usage. The demand for HRT and other hormone therapies to manage menopause-related symptoms such as hot flashes, mood swings, and bone loss is one of the key contributors to the country’s leadership in the market. Germany also has a strong focus on female health, with continuous advancements in fertility treatments and contraceptive solutions. The increasing prevalence of conditions such as polycystic ovary syndrome (PCOS) and infertility among women further drives the demand for synthetic hormones used in fertility treatments. Hormonal treatments such as gonadotropins, estrogen, and progesterone are widely used for in vitro fertilization (IVF) and other assisted reproductive technologies (ART), which have gained popularity in Germany.

Recent Developments

• In September 2023, Ascendis Pharma A/S announced the launch of SKYTROFA® (lonapegsomatropin) in Germany. This growth hormone, approved by the European Union, is indicated for the once-weekly treatment of children and adolescents aged 3 to 18 years who experience growth failure due to insufficient endogenous growth hormone secretion (growth hormone deficiency, or GHD).
• Starting on 1 April 2023, women in England gained access to more affordable hormone replacement therapy (HRT) for managing menopause symptoms. The introduction of the new HRT prescription prepayment certificate (PPC) was expected to benefit approximately 400,000 women, helping them save hundreds of pounds annually, with the cost reduced to less than USD 25 per year. The certificate, available online or at certain pharmacies, could be used multiple times throughout the year. Women experiencing menopause symptoms were now able to access cheaper HRT, which is the primary treatment for managing these symptoms, resulting in significant savings on prescription charges. The newly introduced HRT PPC reduced prescription costs to just USD 24per year, covering a range of eligible HRT items such as patches, tablets, and topical preparations. The certificate could be used as needed throughout the year.
• In December 2023, in a significant step toward shared responsibility in contraception, researchers in the UK have launched the first phase of trials for an innovative non-hormonal male birth control pill. The drug, YCT-529, has been developed by Quotient Sciences, a drug development company based in Nottingham. The trial, which involves 16 British men, represents a major breakthrough in shifting the responsibility of preventing unwanted pregnancies from women to men.
• In September 2023, Besins Healthcare, a global leader in Women's and Men's Reproductive Health, has officially opened its state-of-the-art hormone production facility in Muel, near Zaragoza, Spain. This marks a key milestone in European pharmaceutical history. Constructed in a remarkable timeframe since its foundation in mid-2022, the cutting-edge facility adheres to the highest quality and environmental standards. The plant strengthens Besins Healthcare's commitment to expanding its production capacity in Europe, increasing output by an impressive 30%.

Key Market Players

• Ferring Hungary Ltd
• Novo Nordisk A/S
• Ipsen Biopharm Ltd
• Novartis AG
• Perrigo Company plc
• Sanofi S.A.
• Pfizer Holdings Netherlands B.V.
• Lupin Healthcare Ltd
• GSK plc
• Boehringer Ingelheim International GmbH

Report Scope:

In this report, the Europe Synthetic Hormones Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

·       Europe Synthetic Hormones Market, By Product Type:

o   Steroid Hormones

o   Peptide Hormones

o   Others

·       Europe Synthetic Hormones Market, By Route of Administration:

o   Subcutaneous

o   Oral

o   Intravenous/Intramuscular

o   Others

·       Europe Synthetic Hormones Market, By Application:

o   Diabetes

o   Growth Hormone Deficiency

o   Contraception

o   Male Hypogonadism

o   Menopause

o   Others

·       Europe Synthetic Hormones Market, By End User:

o   Hospital Pharmacies

o   Retail Pharmacies

o   Online Pharmacies

·       Europe Synthetic Hormones Market, By Country:

o   Germany

o   France

o   United Kingdom

o   Italy

o   Spain

o   Russia

o   Poland

o   Bulgaria

o   Finland

o   Portugal

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Europe Synthetic Hormones Market.

Available Customizations:

Europe Synthetic Hormones Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

Company Information

• Detailed analysis and profiling of additional market players (up to five).

Europe Synthetic Hormones Market is an upcoming report to be released soon. If you wish an early delivery of this report or want to confirm the date of release, please contact us at [email protected]