Bone Allografts Market- Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Application (Dental, Spine, Reconstruction & Traumatology, Others), By Type (Cortical Bone Allografts, Cancellous Bone Allografts, Corticocancellous Bone Allografts, Demineralized bone Matrices), By End-user (Hospitals & Dental Clinics, Orthopedic & Trauma Centers, Others), By Region & Competition, 2021-2031F

Forecast Period	2027-2031
Market Size (2025)	USD 1.48 Billion
CAGR (2026-2031)	7.31%
Fastest Growing Segment	Demineralized Bone Matrices
Largest Market	North America
Market Size (2031)	USD 2.26 Billion

Market Overview

The Global Bone Allografts Market will grow from USD 1.48 Billion in 2025 to USD 2.26 Billion by 2031 at a 7.31% CAGR. Bone allografts are natural tissue grafts derived from human donors used to repair skeletal defects, treat fractures, and facilitate spinal fusions. The market is fundamentally driven by the aging global population which increases the prevalence of orthopedic conditions and the rising incidence of sports injuries requiring reconstructive intervention. Additionally, the clinical preference for allografts over autografts supports market growth as it eliminates the morbidity associated with a second surgical harvest site. Improvements in tissue processing technologies that preserve biological integrity while ensuring sterility further reinforce surgeon confidence in these biological solutions.

However, the risk of disease transmission remains a significant challenge that could impede market expansion due to strict regulatory scrutiny and potential product recalls. Ensuring product safety requires rigorous donor screening which can occasionally limit supply availability during periods of high demand. Highlighting the substantial reliance on these products, according to the Association for Advancing Tissue and Biologics, in 2024, approximately 2.5 million tissue transplants were performed annually to restore health and mobility to patients.

Key Market Drivers

The increasing volume of spinal fusion and joint reconstruction procedures acts as a primary catalyst for the Global Bone Allografts Market. As the aging population faces degenerative conditions like osteoarthritis, the necessity for surgical interventions rises, directly boosting the consumption of allograft tissues for structural support. Surgeons utilizing these biological implants can restore patient mobility without the morbidity associated with autograft harvesting, leading to sustained adoption. This procedural surge is evident in industrial performance; according to Enovis Corporation, February 2025, in the 'Fourth Quarter and Full Year 2024 Results', the company reported that net sales in its Reconstructive segment grew 59% on a reported basis, underscoring the accelerating demand for joint reconstruction solutions. Further reflecting this sector's scale, according to Zimmer Biomet, in 2025, the company recorded full-year 2024 net sales of $7.68 billion, driven by resilient growth across its orthopedic product categories.

Advancements in regenerative medicine and bio-implants are simultaneously propelling market growth by enhancing the safety and efficacy of bone grafting. Innovations in tissue processing, particularly in cellular bone matrices and advanced sterilization, have reduced disease transmission risks while preserving the osteoinductive properties essential for healing. These improvements foster clinical confidence, encouraging the shift toward high-quality allografts in complex orthopedic surgeries. The commercial success of companies focusing on these advanced biologics validates this momentum; according to Orthofix Medical Inc., February 2025, in the 'Fourth Quarter and Full-Year 2024 Results', the company achieved full-year net sales of $799.5 million, representing a 7% increase attributed to the robust performance of its spine and bone growth therapy portfolios.

Download Free Sample Report

Key Market Challenges

The risk of disease transmission stands as a significant challenge hampering the growth of the Global Bone Allografts Market. The potential for transmitting pathogens, such as bacteria or viruses, necessitates rigorous donor screening and strict regulatory adherence, which significantly reduces the pool of eligible donors. This exclusionary process limits the availability of raw materials, causing supply shortages that cannot easily meet the rising clinical demand for orthopedic and spinal procedures. Additionally, the fear of contamination events and subsequent product recalls creates market volatility and can diminish surgeon confidence in allograft safety, leading to hesitation in their adoption compared to synthetic alternatives.

This environment of heightened scrutiny imposes substantial operational constraints on market players. The need for meticulous compliance creates high barriers to entry and elevates operational costs, preventing rapid market expansion. Illustrating the consolidated infrastructure required to manage these risks, according to the Association for Advancing Tissue and Biologics, in 2025, there were more than 120 accredited tissue banks operating to ensure the safety and availability of donated human tissue. This restricted number of qualified suppliers highlights how safety-driven regulations directly limit the market's capacity to scale operations and volume.

Key Market Trends

The rising adoption of Demineralized Bone Matrix (DBM) formulations is transforming the market as surgeons seek grafts combining structural stability with enhanced osteoinductive potential. Unlike standard mineralized allografts, DBM undergoes acid extraction to expose bone morphogenetic proteins (BMPs), accelerating fusion in complex spinal procedures. Manufacturers are consequently developing advanced DBM putties and strips with superior handling characteristics to improve surgical outcomes in non-union fractures. Reflecting this demand, according to Orthofix Medical Inc., November 2025, in the 'Third Quarter 2025 Financial Results', the company's Bone Growth Therapies segment achieved net sales of $61.2 million, representing a 6% increase compared to the prior year.

The expansion of allograft applications in dental implantology is becoming a critical trajectory as esthetic tooth replacement necessitates robust alveolar ridge preservation. Surgeons increasingly utilize particulate and block allografts for sinus lifts and socket preservation to maintain bone volume and support implant stability without secondary harvesting. This trend is supported by application-specific allograft shapes designed to fit precise periodontal defects, streamlining chairside workflows. Validating this sector's scale, according to Straumann Group, February 2025, in the '2024 Full-year report', the company achieved full-year revenue of CHF 2.5 billion with 13.7% organic growth, underpinned by sustained demand for premium implantology and regenerative solutions.

Segmental Insights

The Demineralized Bone Matrices segment is identified as the fastest-growing area within the global bone allografts market, driven by its enhanced osteoinductive capabilities and broad versatility. Surgeons increasingly prefer these matrices because they are processed to expose bone morphogenetic proteins that actively stimulate bone regeneration, making them highly effective for spinal fusions and trauma surgeries. Additionally, the availability of these products in adaptable forms, such as gels and putties, aligns with the safety standards set by the U.S. Food and Drug Administration for human tissue, further encouraging clinical adoption and market expansion.

Regional Insights

North America maintains a dominant position in the global bone allografts market due to a well-established healthcare infrastructure and a high volume of orthopedic and dental surgical procedures. The region benefits from a robust regulatory framework enforced by the U.S. Food and Drug Administration, which ensures stringent safety standards for tissue processing. Additionally, the widespread presence of tissue banks accredited by the American Association of Tissue Banks supports a reliable supply chain. This accessibility, combined with rising demand for reconstructive surgeries among an aging demographic, secures the region's market leadership.

Recent Developments

• In March 2025, MTF Biologics expanded its strategic partnership with Kolosis BIO to broaden the distribution of its allograft solutions. Under this extended agreement, the partner company increased its portfolio to include specific demineralized cortical bone matrix formulations, such as putty and mix options. These products were intended to assist surgeons in addressing various orthopedic challenges, including spinal and joint fusions. The collaboration reinforced a shared commitment to delivering high-quality tissue grafts derived from donated gifts, ensuring that advanced biologic technologies remained accessible to healthcare providers and patients requiring bone void fillers for reconstruction.
• In November 2024, Neoss Inc. expanded its biomaterials portfolio with the commercial launch of the NeoGenix Extraction Allograft. This new product was composed of 100% human allograft tissue, blending demineralized bone fibers with mineralized bone particulate to support bone regeneration. The graft was designed as a convenient plug shape to eliminate the need for mixing or additional membranes, thereby streamlining the workflow for dental practitioners. By combining cortical and cancellous materials, the solution aimed to create an optimal environment for bone growth while preserving the patient's bone structure for future implant treatments.
• In August 2024, LifeNet Health announced the launch of a new bone allograft solution developed in collaboration with Johnson & Johnson MedTech. This product, designed to address voids and defects in orthopedic spine and trauma procedures, featured advanced fiber technology that combined mineralized bone chips with moldable demineralized fibers. The launch marked the company's expansion into the demineralized bone matrix market, utilizing a design intended to enhance surgical efficiency and handling. The commercially released graft was made available to surgeons through the partner's extensive medical technology distribution network, aiming to expedite procedural workflows.
• In January 2024, Ossium Health entered into a strategic collaborative agreement with Extremity Medical to distribute a viable bone matrix allograft across the United States. This partnership combined a proprietary cellular therapeutic platform with an established orthopedic product network to supply surgeons treating musculoskeletal defects. The specific allograft involved in this agreement was derived from vertebral bones of organ donors and characterized by a high cancellous bone ratio to support healing. The collaboration aimed to leverage a robust distribution channel to provide this novel bone reconstruction solution to hospitals and ambulatory surgery centers nationwide.

Key Market Players

• Zimmer Biomet inc.
• Medtronic inc.
• Lynch Biologics, LLC
• Biomatlante S.A
• Stryker Corporation
• Royal Biologics, Inc.
• Johnsons & Johnsons
• Smith & Nephew plc
• Baxter International Inc
• Xtant Medical Holdings

By Application	By Type	By End-user	By Region
Dental Spine Reconstruction & Traumatology Others	Cortical Bone Allografts Cancellous Bone Allografts Corticocancellous Bone Allografts Demineralized bone Matrices	Hospitals & Dental Clinics Orthopedic & Trauma Centers Others	North America Europe Asia Pacific South America Middle East & Africa

Report Scope:

In this report, the Global Bone Allografts Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

• Bone Allografts Market, By Application:

• Dental
• Spine
• Reconstruction & Traumatology
• Others

• Bone Allografts Market, By Type:

• Cortical Bone Allografts
• Cancellous Bone Allografts
• Corticocancellous Bone Allografts
• Demineralized bone Matrices

• Bone Allografts Market, By End-user:

• Hospitals & Dental Clinics
• Orthopedic & Trauma Centers
• Others

• Bone Allografts Market, By Region:

• North America
• United States
• Canada
• Mexico
• Europe
• France
• United Kingdom
• Italy
• Germany
• Spain
• Asia Pacific
• China
• India
• Japan
• Australia
• South Korea
• South America
• Brazil
• Argentina
• Colombia
• Middle East & Africa
• South Africa
• Saudi Arabia
• UAE