Surgical Sealants & Adhesives Market- Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Type (Natural/Biological v/s Synthetic/Semi-Synthetic), By Natural/Biological (Fibrin Sealants, Collagen Based Adhesives, Gelatin Based Adhesives), By Synthetic/Semi-Synthetic (Cyanoacrylates, Polymeric Hydrogels, Urethane Based Adhesives), By Indication (Tissue Sealing, Surgical Hemostasis, Tissue Engineering), By Application (Cardiovascular Surgery, General Surgery, CNS Surgery, Orthopedic Surgery, Cosmetic Surgery, Others), By Region and Competition, 2020-2030F

Market Overview

Surgical Sealants & Adhesives Market was valued at USD 2.41 Billion in 2024 and is expected to reach USD 3.87 Billion by 2030 with a CAGR of 8.31%.

The global surgical sealants and adhesives market is witnessing significant growth, driven by their critical role in modern surgical procedures across cardiovascular, cosmetic, orthopedic, and general surgery applications. These products, including fibrin sealants, cyanoacrylates, and hydrogels, facilitate wound closure, reduce postoperative complications, and enhance patient recovery by minimizing blood loss and infection risks. The market is propelled by the rising prevalence of chronic diseases, such as cardiovascular disorders and cancer, which increase surgical interventions globally. The World Health Organization estimates millions of surgeries performed annually, underscoring the need for effective sealing solutions. Additionally, the shift toward minimally invasive procedures, supported by policies like the U.S. Affordable Care Act, boosts demand for advanced sealants that offer rapid healing and reduced scarring.

The market is further driven by growing healthcare expenditure in emerging economies and the aging population, which is more prone to surgical interventions. Regulatory frameworks, such as the FDA’s approval processes and the EU’s Medical Device Regulation, encourage the development of biocompatible and bioresorbable sealants, aligning with patient safety goals. The cosmetics industry increasingly adopts these products for scar-free outcomes, while cardiovascular surgeries leverage them for hemostasis. Despite challenges like high costs and regulatory hurdles, innovations in bio-based and synthetic formulations enhance market potential. The forecast period of 2020–2030F is expected to see sustained growth as manufacturers focus on patient-centric solutions and healthcare systems prioritize efficient surgical outcomes.

Key Market Drivers

Rising Prevalence of Chronic Diseases and Surgical Procedures

The global surgical sealants and adhesives market is significantly driven by the rising prevalence of chronic diseases, including cardiovascular disorders, cancer, and diabetes, which necessitate frequent surgical interventions. According to the World Health Organization (WHO), more than 310 million major surgical procedures are performed annually worldwide, reflecting the growing burden of chronic conditions. The Centers for Disease Control and Prevention (CDC) reports over 1.9 million new cancer cases annually in the U.S. (2023), many requiring surgical management. Similarly, the World Heart Federation estimates that cardiovascular diseases account for over 20.5 million deaths annually (2023), with millions of patients undergoing bypass, valve repair, and transplant surgeries.

Policies promoting early detection and treatment, such as the EU’s Cancer Mission targeting 3 million lives saved by 2030, further increase surgical volumes and drive demand for effective sealants to manage tissue closure and bleeding. Manufacturers are innovating with fibrin and cyanoacrylate-based sealants that offer rapid hemostasis and biocompatibility for complex surgeries. In India, government programs like Ayushman Bharat, which aims to provide healthcare coverage to over 500 million citizens, enhance access to surgical care, boosting market adoption. This trend is expected to accelerate through 2030, with chronic disease prevalence and surgical needs expanding worldwide.

Growing Demand for Minimally Invasive Surgeries

The rising adoption of minimally invasive surgeries (MIS) is a major growth driver, as these procedures require advanced sealants for tissue bonding, bleeding control, and faster recovery. According to the American Society of Plastic Surgeons (ASPS), over 1.3 million minimally invasive reconstructive procedures were performed in the U.S. in 2022. The Global Laparoscopy Devices Market report highlights that MIS accounts for over 30% of all surgical procedures globally, with laparoscopic and robotic-assisted surgeries expanding rapidly.

Government policies are also accelerating MIS adoption. For example, U.S. Medicare coverage supports laparoscopic and robotic procedures, while Japan’s healthcare modernization initiatives promote advanced surgical technologies. In Asia-Pacific, China performed more than 4.5 million laparoscopic surgeries in 2022, supported by healthcare infrastructure investments. Manufacturers are focusing on bioresorbable sealants, hydrogels, and polyethylene glycol (PEG)-based adhesives that enhance tissue adhesion and reduce complications in MIS.

The World Health Organization emphasizes MIS benefits, such as 40–60% reduction in hospital stays and fewer postoperative infections, further strengthening their adoption. The integration of sealants into robotic-assisted platforms like the da Vinci Surgical System, now installed in 7,500+ hospitals worldwide (2023), is boosting precision and demand. As MIS becomes a global surgical standard, the market for sealants and adhesives is projected to witness strong growth through 2030.

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Key Market Challenges

High Costs of Advanced Sealants and Adhesives

The high cost of advanced surgical sealants and adhesives poses a significant challenge, particularly in cost-sensitive regions like Asia-Pacific and the Middle East & Africa. Developing bioresorbable and biocompatible formulations requires substantial R&D investments, increasing product prices. This limits adoption in low-income healthcare systems, where traditional sutures remain prevalent.

Smaller hospitals and clinics struggle to afford these products, hindering market penetration. The need for clinical trials to meet regulatory standards, such as FDA and EMA requirements, further escalates costs. Addressing this challenge requires cost-effective production and reimbursement policies, but economic constraints pose barriers. The industry must navigate these cost issues to ensure broader adoption through 2030.

Stringent Regulatory Approvals

Stringent regulatory approvals present a major challenge, as agencies like the FDA and EMA enforce rigorous standards for safety and efficacy. Compliance requires extensive clinical data, increasing development timelines and costs. This issue is prominent in Europe, where the Medical Device Regulation demands comprehensive testing for new sealants.

Smaller manufacturers face difficulties meeting these requirements, limiting innovation. The shift to bio-based sealants involves additional regulatory scrutiny, hindering scalability in high-volume markets like Asia-Pacific. Addressing this requires streamlined approval processes, but regulatory complexity persists. The industry must overcome these hurdles to sustain growth through 2030.

Key Market Trends

Development of Bio-Based and Bioresorbable Sealants

The development of bio-based and bioresorbable surgical sealants is a key trend, driven by demand for biocompatible solutions that reduce postoperative complications. Manufacturers like Baxter are focusing on fibrin and collagen-based sealants that degrade naturally, aligning with policies like the EU’s Green Deal. This trend is prominent in North America, where hospitals prioritize patient safety.

These sealants improve outcomes in cardiovascular and cosmetic surgeries, reducing infection risks. Reports highlight increased R&D investments in bio-based materials, enhancing tissue regeneration. This trend is expected to drive growth through 2030, as sustainability and patient-centric care gain traction.

Integration of Nanotechnology in Sealants

The integration of nanotechnology in surgical sealants is a significant trend, offering enhanced adhesion and antimicrobial properties. This trend is gaining traction in Europe, where companies develop nanostructured sealants for neurosurgery and orthopedics. Reports note improved wound healing and reduced infection rates, aligning with healthcare quality goals.

Nanotechnology enables precise application in minimally invasive procedures, supporting high-precision surgeries. Government funding for advanced materials, such as in the U.S., drives R&D. This trend is expected to propel growth through 2030, as nanotechnology enhances sealant performance across applications.

Segmental Insights

Type Insights

Based on type, the natural/biological sealants segment was anticipated to dominate the global Surgical Sealants & Adhesives market and maintain strong growth momentum throughout the forecast period. This dominance is driven by the segment’s biocompatibility, biodegradability, and reduced risk of adverse reactions, making natural sealants highly preferred for sensitive surgical applications. These sealants promote faster healing and minimize infection risks, which is critical in medical procedures. Increasing demand for minimally invasive surgeries and rising patient awareness about safety and efficacy further bolster growth. Advances in biotechnology and the development of innovative formulations are enhancing the performance and versatility of natural sealants, ensuring their sustained adoption. Growing healthcare infrastructure, especially in emerging markets, also contributes to the expanding use of natural/biological surgical sealants globally.

Application Insights

Based on the application, the Cosmetic Surgery segment has emerged as the fastest-growing segment in the global Surgical Sealants & Adhesives market and is projected to sustain its strong growth momentum over the forecast period. This rapid growth is driven by the rising number of cosmetic and minimally invasive procedures worldwide, fueled by increasing consumer awareness and demand for aesthetic enhancements. Surgical sealants and adhesives play a crucial role in improving wound closure, reducing scarring, and accelerating healing in cosmetic surgeries. Advances in adhesive formulations that offer better biocompatibility and ease of application further boost their adoption. The growing availability of cosmetic surgery services in emerging markets and rising healthcare expenditure support the expanding use of surgical sealants and adhesives in this segment globally.

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Regional Insights

Based on region, Asia-Pacific has emerged as the largest market in the global Surgical Sealants & Adhesives industry, driven by rapidly expanding healthcare infrastructure, increasing number of surgical procedures, and rising healthcare expenditure. The region’s growing population, coupled with a surge in chronic diseases and trauma cases, fuels demand for advanced wound closure solutions like surgical sealants and adhesives. Improving access to quality healthcare and rising awareness about minimally invasive surgeries contribute to market growth. Countries such as China, India, Japan, and South Korea are key contributors due to their large patient base and investments in medical technology. Favorable government initiatives and increasing medical tourism also support the expansion of the surgical sealants and adhesives market in the Asia-Pacific region.

Recent Development

• In July 2023, H.B. Fuller expanded its footprint in medical adhesives by acquiring Adhezion Biomedical. This strategic move bolsters its product portfolio in surgical sealants and adhesives, a key growth segment in the roughly USD 8 billion healthcare adhesives market.
• In March 2023, Animus Surgical introduced Membra, a transparent, biodegradable hydrogel sealant for veterinary use. It forms a protective barrier over wounds, remaining for up to two weeks before naturally degrading—eliminating the need for bandaging.
• In November 2023, Ethicon (Johnson & Johnson’s division) launched Ethizia, a hemostatic sealing patch designed to control bleeding during surgery, reinforcing its leadership in surgical sealant innovations.
• In November 2023, Pramand LLC introduced the CraniSeal system in the U.S., offering a new solution tailored for cranial surgical applications.
• In 2021, Becton Dickinson (BD) integrated Tissuemed’s innovative TissuePatch surgical sealant films into its portfolio. This acquisition enables BD to strengthen its global offerings with advanced bioadhesive technologies used across thoracic, general, and neurosurgery.
• Gecko Biomedical has changed its name to Tissium SA to reflect its growing company mission and vision to create polymer technology that proposes a sutureless way to treat peripheral nerves. Along with this, they received an investment of USD 51.8 million from a Series C funding round, in July 2021.
• Ethicon, Inc. (Johnson & Johnson) launched VISTASEAL, fibrin-based sealant for use in surgeries to manage bleeding. This product was launched in 2019.
• In 2018, Baxter International, Inc. acquired two surgical sealants from the portfolio of Mallinckrodt. These products were RECOTHROM Thrombin topical hemostat and PREVELEAK sealant. This acquisition helped Baxter expand its product offerings and improve its market positioning.

Key Market Players

• Tricol Biomedical, Inc.
• Baxter International, Inc.
• Johnson & Johnson
• Becton, Dickinson and Company
• CryoLife, Inc.
• Cardinal Health, Inc.
• B. Braun Melsungen AG
• Integra Lifesciences Holdings Corporation
• Medline Industries, Inc.
• Adhezion Biomedical, LLC

Report Scope:

In this report, global surgical sealants & adhesives market has been segmented into following categories, in addition to the industry trends which have also been detailed below:

·         Surgical Sealants & Adhesives Market, by type:

• Natural/Biological
• Fibrin Sealants
• Collagen Based Adhesives
• Gelatin Based Adhesives
• Synthetic/Semi-Synthetic
• Cyanoacrylates
• Polymeric Hydrogels
• Urethane Based Adhesives
• Surgical Sealants & Adhesives Market, By Indication:
• Tissue Sealing
• Surgical Hemostasis
• Tissue Engineering  
• Surgical Sealants & Adhesives Market, By Application:
• Cardiovascular Surgery
• General Surgery
• CNS Surgery
• Orthopedic Surgery
• Cosmetic Surgery
• Others
• Surgical Sealants & Adhesives Market, By Region:
• North America
• United States
• Canada
• Mexico
• Asia-Pacific
• China
• India
• South Korea
• Australia
• Japan
• Europe & CIS
• Germany
• France
• United Kingdom
• Spain
• Italy
• South America
• Brazil
• Argentina
• Colombia
• Middle East & Africa

•         South Africa
•        Saudi Arabia
•        UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in global Surgical Sealants & Adhesives market.

Available Customizations:

With the given market data, TechSci Research offers customizations according to a company’s specific needs. The following customization options are available for the report:

Company Information

• Detailed analysis and profiling of additional market players (up to five).

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