Sequencing Reagents Market- Global Industry Size, Share, Trends, Opportunity and Forecast, Segmented By Technology (Sanger Sequencing, Next-Generation Sequencing, Third Generation Sequencing), By Type (Library Kits, Template Kits, Control Kits, Sequencing Kits, Others), By Application (Oncology, Reproductive Health, Clinical Investigation, Agrigenomics & Forensics, Others), By Region and Competition, 2021-2031F

Forecast Period	2027-2031
Market Size (2025)	USD 9.57 Billion
CAGR (2026-2031)	10.54%
Fastest Growing Segment	Next Generation Sequencing
Largest Market	North America
Market Size (2031)	USD 17.46 Billion

Market Overview

The Global Sequencing Reagents Market will grow from USD 9.57 Billion in 2025 to USD 17.46 Billion by 2031 at a 10.54% CAGR. Sequencing reagents comprise the essential chemical kits, enzymes, and consumables utilized for library preparation and nucleic acid analysis in clinical or research applications. The market is fundamentally driven by the escalating prevalence of chronic diseases and the subsequent demand for precision medicine which relies on accurate genomic profiling. According to the American Cancer Society, in 2025, approximately 2,041,910 new cancer cases are projected to occur in the United States, underscoring the critical need for advanced diagnostic capabilities. This rising disease burden necessitates the continuous procurement of high quality reagents for mutation detection and targeted therapy selection.

However, market expansion faces a significant challenge regarding the high capital investment required for establishing sequencing infrastructure. Many smaller laboratories and institutions in emerging economies struggle with the substantial costs of acquiring and maintaining advanced sequencing platforms which directly limits their consumption of recurring reagent supplies. This financial barrier effectively restricts the addressable market and slows the global adoption of advanced sequencing technologies in resource limited settings.

Key Market Drivers

Technological advancements in next-generation sequencing platforms are significantly propelling the Global Sequencing Reagents Market. The introduction of high-throughput systems has reduced sequencing costs and increased data output, necessitating a higher volume of consumable kits for library preparation and flow cell usage. As laboratories transition to these high-capacity instruments to maximize efficiency, the recurring revenue from associated reagents has expanded. For instance, reflecting this shift towards high-output sequencing utilization, According to Oxford Nanopore Technologies, September 2025, in the 'Interim results for the six months ended 30 June 2025', revenue from the PromethION product range increased to £51.1 million. This growth underscores how platform innovation directly stimulates the continuous consumption of specialized chemical reagents required for large-scale genomic operations.

Simultaneously, a surge in genomics research funding and government initiatives is accelerating market demand by enabling large-scale population studies. Public and private investments are increasingly directed toward precision medicine programs and pangenome references, which rely heavily on extensive sequencing workflows. According to Genome Canada, March 2025, in the 'News release', the organization launched the Canadian Precision Health Initiative with an $81 million investment to build a diverse genomic data resource. Such financial injections allow research centers to procure necessary consumables for thousands of samples. Furthermore, highlighting the continued support for genomic diversification, According to News-Medical.Net, in 2025, Washington University School of Medicine received $14 million to renew the Human Pangenome Reference Sequencing Project, ensuring sustained reagent procurement for foundational genomic research.

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Key Market Challenges

The significant capital investment required to establish sequencing infrastructure acts as a substantial barrier to the expansion of the Global Sequencing Reagents Market. High costs associated with acquiring genomic platforms effectively exclude smaller laboratories and research institutions in resource-constrained regions from entering the space. Because reagent consumption is intrinsically linked to the installed base of sequencing instruments, the inability of these entities to surmount initial financial barriers directly limits the volume of recurring sales. Without the budget to procure the necessary hardware, these potential customers cannot generate demand for the associated chemical kits and consumables, thereby restricting the total addressable market.

This economic pressure is further intensified by contractions in research funding, which serves as a critical lifeline for capital equipment procurement in the academic and clinical sectors. According to the Association of American Medical Colleges, in 2025, the National Institutes of Health committed approximately $5 billion less in research grants to United States institutions compared to the previous year. Such significant reductions in available capital constrain the purchasing power of laboratories, compelling them to defer infrastructure upgrades or expansion. Consequently, this stagnation in platform adoption creates a downstream bottleneck that severely hampers the volume growth of the sequencing reagents sector.

Key Market Trends

The market is witnessing a decisive surge in demand for single-cell and spatial genomics consumables, driven by the critical need to resolve cellular heterogeneity that bulk sequencing often obscures. Researchers are increasingly adopting complex reagent kits capable of barcoding individual cells or mapping gene expression directly to tissue architecture, workflows that command a significantly higher price point per sample compared to standard library preparation. This shift towards high-resolution biological analysis is sustaining revenue growth in the reagents sector even as capital equipment sales face volatility. For instance, highlighting this specific demand resilience, According to 10x Genomics, January 2025, in the 'Preliminary Select Fourth Quarter and Full Year 2024 Results', consumables revenue reached approximately $493.4 million for the full year 2024, representing 3% growth over the prior year despite a challenging instrument sales environment.

Simultaneously, the development of specialized reagents for liquid biopsy and oncology profiling is creating a robust, high-volume sub-segment. Laboratories are actively procuring advanced chemistry sets designed for the ultra-sensitive detection of circulating tumor DNA (ctDNA) and methylation patterns, which are essential for non-invasive cancer screening and therapy monitoring. These precision diagnostic workflows require highly optimized enzymes and enrichment panels to ensure accuracy, significantly increasing the frequency of recurring reagent orders from clinical providers. Underscoring this expanding clinical utility, According to Guardant Health, February 2025, in the 'Fourth Quarter and Full Year 2024 Financial Results', the company reported that oncology clinical test volumes grew by 20% year-over-year to approximately 206,700 tests for the full year 2024, directly fueling the consumption of these specialized molecular diagnostics consumables.

Segmental Insights

Next Generation Sequencing constitutes the fastest-growing segment in the global sequencing reagents market, driven by widespread adoption in clinical oncology and precision medicine. This growth is primarily attributed to the decreasing operational costs and high throughput capabilities of modern platforms, which necessitate a steady supply of library preparation kits and consumables. Additionally, the increasing authorization of genomic-based companion diagnostics by regulatory bodies such as the US FDA encourages healthcare providers to implement these workflows, thereby creating sustained demand for the associated reagents required for routine testing.

Regional Insights

North America currently holds the commanding share of the Global Sequencing Reagents Market, driven by extensive research and development activities and the domestic presence of major manufacturers. The dominance of the United States is largely attributed to significant government funding for genomic studies, particularly through organizations such as the National Institutes of Health. This support facilitates large-scale population sequencing projects that require substantial volumes of reagents. Furthermore, the widespread adoption of genomic testing in clinical diagnostics and ongoing advancements in precision medicine continue to sustain high regional demand.

Recent Developments

• In September 2024, MGI Tech announced the global rights to commercialize its new nanopore sequencing products, the CycloneSEQ-WT02 and CycloneSEQ-WY01. These systems and their associated reagents incorporate advanced protein engineering and novel flow cell designs to enable high-accuracy, long-read sequencing. The technology allows for the sequencing of long DNA and RNA molecules without fragmentation, supporting applications that require real-time analysis and rapid detection. This launch represented a strategic expansion of the company's multi-omics portfolio, aiming to provide researchers with a complete toolkit for diverse genomic applications, including complex full-length genome assembly and public health surveillance.
• In June 2024, Illumina announced the complete integration of its latest XLEAP-SBS chemistry into the reagents for its NextSeq 1000 and NextSeq 2000 sequencing instruments. This product update included the commercial availability of P1, P2, and P3 flow cells featuring the enhanced chemistry, which was engineered to deliver faster run times and higher data quality. The company stated that the new reagents provide approximately 20% faster turnaround times, enabling laboratories to increase their project scale and adopt multiomic approaches more efficiently. Early adopters reported improved stability and read quality, positioning the chemistry as a robust solution for applications such as single-cell and whole-exome sequencing.
• In April 2024, Element Biosciences began accepting orders for the AVITI24 system, a new platform that features the company's proprietary Teton chemistry. This launch introduced a suite of reagents that allows for the simultaneous sequencing and cyto-profiling of DNA, RNA, proteins, and cell morphology within a single experiment. The Teton chemistry enables researchers to obtain comprehensive multi-omic read-outs in under 24 hours without the need for complex library preparation. By facilitating the in-depth exploration of molecular linkages in cancer cells, these reagents were developed to maximize data value per sample and drive transformative discoveries in therapeutic response and resistance.
• In February 2024, Pacific Biosciences announced the launch of two new high-throughput library preparation reagents, the HiFi Prep Kit 96 and HiFi Plex Prep Kit 96, specifically optimized for the Revio sequencing system. These new kits were designed to provide automated and scalable solutions that enable users to streamline the process of preparing, pooling, and loading samples for long-read sequencing. The company reported that these reagents offer a 40% reduction in costs and a 60% decrease in workflow time, aiming to eliminate significant labor and expense bottlenecks. This development was intended to support large-scale projects in microbial and metagenome sequencing by making high-throughput genotyping more accessible.

Key Market Players

• Thermo Fisher Scientific, Inc
• Abzena Ltd
• Illumina, Inc.
• QIAGEN N.V.
• Pacific Biosciences of California, Inc.
• F. Hoffmann-La Roche Ltd.
• Oxford Nanopore Technologies Plc.
• Agilent Technologies, Inc.
• Fluidigm Corporation
• Integrated DNA Technologies, Inc

By Technology	By Type	By Application	By Region
Sanger Sequencing Next-Generation Sequencing Third Generation Sequencing	Library Kits Template Kits Control Kits Sequencing Kits Others	Oncology Reproductive Health Clinical Investigation Agrigenomics & Forensics Others	North America Europe Asia Pacific South America Middle East & Africa

Report Scope:

In this report, the Global Sequencing Reagents Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

• Sequencing Reagents Market, By Technology:

• Sanger Sequencing
• Next-Generation Sequencing
• Third Generation Sequencing

• Sequencing Reagents Market, By Type:

• Library Kits
• Template Kits
• Control Kits
• Sequencing Kits
• Others

• Sequencing Reagents Market, By Application:

• Oncology
• Reproductive Health
• Clinical Investigation
• Agrigenomics & Forensics
• Others

• Sequencing Reagents Market, By Region:

• North America
• United States
• Canada
• Mexico
• Europe
• France
• United Kingdom
• Italy
• Germany
• Spain
• Asia Pacific
• China
• India
• Japan
• Australia
• South Korea
• South America
• Brazil
• Argentina
• Colombia
• Middle East & Africa
• South Africa
• Saudi Arabia
• UAE