|
Forecast Period
|
2024-2028
|
|
Market Size (2022)
|
USD 220.30 Million
|
|
CAGR (2023-2028)
|
17.20%
|
|
Fastest Growing Segment
|
Academic & Research
Institutes
|
|
Largest Market
|
North America
|
Market Overview
Global Nanopore Sequencing Market has valued at USD 220.30 Million in
2022 and is anticipated to project impressive growth in the forecast period
with a CAGR of 17.20% through 2028. Nanopore sequencing is a third-generation
technique utilized for the sequencing of biopolymers, specifically
polynucleotides such as DNA or RNA, along with other components. This advanced
method enables the analysis of single molecule DNA or RNA without the need for
PCR amplification or chemical labeling of the sample. With its potential for
cost-effective genotyping, enhanced mobility for testing, and rapid sample
processing with real-time results, nanopore sequencing stands at the forefront
of sequencing technologies. By measuring fluctuations in electric current as
the molecule passes through a nanopore, the sequence of the given nucleic acid
can be accurately identified. As a cutting-edge fourth-generation technology,
nanopore sequencing involves the passage of individual DNA or RNA strands
through minuscule protein channels called nanopores. Embedded within an
electrically resistant membrane, these nanopores induce alterations in ion
current, facilitating the determination of base sequences and modifications.
This mechanism offers invaluable insights in genomics research.
Key Market Drivers
Increase In Demand for DNA Sequencing For Various Application For
Research
The increase in demand for DNA sequencing across various research
applications is driving a surge in the demand for nanopore sequencing
technology. Nanopore sequencing is a revolutionary method that allows for the
real-time, single-molecule analysis of DNA, RNA, and other biomolecules. Its
versatility and unique advantages make it increasingly popular in the fields of
genomics, genetics, and beyond.
One of the primary drivers for the growing demand of nanopore sequencing
is its broad range of applications. Researchers are using nanopore sequencing
for diverse purposes, including genome sequencing, metagenomics, epigenomics,
transcriptomics, and more. Its ability to directly read long DNA strands and
detect base modifications in real-time offers a comprehensive view of genetic
information, enabling scientists to address complex biological questions. Furthermore,
nanopore sequencing is known for its portability and rapid turnaround time.
Compact nanopore sequencers, such as those offered by Oxford Nanopore Technologies, allow researchers to perform sequencing
experiments in a variety of settings, including remote or field-based
environments. This feature has opened up new possibilities for on-site genomics
research, infectious disease monitoring, and environmental analysis.
Additionally, the continuous advancement of nanopore sequencing
technology is expanding its applications further. Improved accuracy, longer
read lengths, and lower sequencing costs are making nanopore sequencing more
attractive to researchers. As the technology matures and becomes more
cost-effective, it is increasingly integrated into research pipelines and
clinical diagnostics. The surge in
demand for DNA sequencing across diverse research areas is propelling the
adoption of nanopore sequencing technology. Its versatility, portability, and
continuous improvements make it a valuable tool for scientists seeking
comprehensive genetic insights and real-time data, contributing to
groundbreaking discoveries and advancements in various fields of study. As nanopore
sequencing continues to evolve, its role in genomics and beyond is likely to
expand even further, driving sustained demand for this innovative technology.
Partnerships and Acquisition to Boost Adoption and Co-Develop Advanced
Solutions
The rapidly growing nanopore sequencing market has witnessed a multitude
of strategic partnerships and acquisitions by key market players. These
collaborative endeavors, driven by a shared vision, not only aim to amplify the
adoption of this cutting-edge technology for clinical applications but also to
collectively foster the development of state-of-the-art sequencing platforms
that will truly revolutionize the field.
By leveraging the expertise, knowledge, and resources of multiple
stakeholders, these alliances seek to unlock the full potential of nanopore
sequencing. Through collaborative efforts, advancements in genomic research and
precision medicine can be propelled to unprecedented levels, paving the way for
groundbreaking discoveries and personalized treatments.
The significance of these strategic alliances and acquisitions within
the market cannot be overstated. They serve as a testament to the immense
potential and transformative power of nanopore sequencing in shaping the future
of healthcare and personalized medicine. These partnerships lay a solid
foundation for continued innovation, pushing the boundaries of what is possible
and opening new horizons in the field of genomics.
As the nanopore sequencing market continues to evolve, these strategic
alliances will play a crucial role in driving advancements, accelerating
research, and ultimately improving patient outcomes. The collaborative efforts
of industry leaders underscore the commitment to innovation and the shared goal
of revolutionizing healthcare through the power of nanopore sequencing
technology.
Introduction Of Internet of Things
The introduction of Internet of Things (IoT) has greatly benefited
nanopore technology. With the ability to easily connect sequencers to other
technical systems, healthcare professionals can now monitor DNA samples on
shared cloud computing labs. This advancement is anticipated to not only aid in
the growth of the market in the forecast period but also revolutionize genomics
by expanding its applications to a wider range of needs. The convergence of
ultrafast nanopore sequencing, biosensors, cloud computing, computational
intelligence algorithms, and other related technologies has paved the way for
new possibilities in genomics research.
Moreover, nanopore-based sequencers, as the fourth-generation DNA
sequencing technology, hold immense potential. They offer the ability to
quickly and reliably sequence the entire human genome for less than USD1000,
and possibly even less than USD100. The utilization of single-molecule
techniques by this technology also enables further study of the intricate
interactions between DNA and proteins, as well as between different proteins.
This enhanced understanding of molecular interactions opens up new opportunities
for advancements in various fields, including medicine, biotechnology, and
beyond.
Increase In R&D On Nanopore sequencing
The increase in research and development (R&D) efforts focused on nanopore
sequencing is significantly driving up the demand for nanopore sequencing.
Nanopore sequencing, a cutting-edge method in genomics, relies on the use of
nanopores, tiny openings at the nanoscale level, to analyze individual DNA or
RNA molecules as they pass through these pores. Intensive R&D investments are leading to
continuous advancements in nanopore sequencing. Researchers are working to
refine the design, materials, and manufacturing processes of nanopore
sequencing devices. These improvements result in more reliable and accurate
sequencing platforms, which in turn boost the appeal of nanopore sequencing for
various applications. R&D efforts are driving down the cost of producing
nanopore sequencing devices and reagents. As manufacturing processes become
more efficient and scalable, the overall cost of nanopore sequencing decreases,
making it more accessible to a wider range of researchers and laboratories.
Longer read lengths are a crucial aspect of sequencing technology, as
they enable researchers to decipher complex genomic regions and perform de novo
sequencing more effectively. R&D endeavors are extending the read lengths
achievable with nanopore sequencing, further enhancing its utility in genomics
research. Ongoing research into nanopore sequencing is uncovering new
applications beyond genomics. These include epigenetics, structural biology,
and the analysis of various biomolecules, such as proteins and RNA. As the
range of applications widens, the demand for nanopore sequencing grows across
diverse scientific disciplines. R&D is driving the development of smaller
and more portable nanopore sequencing devices. These compact instruments can be
utilized in various settings, including remote or point-of-care environments,
broadening the potential use cases for nanopore sequencing.
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Key Market Challenges
Higher Error Rate and Experimental Barriers
While nanopore sequencing technology offers numerous advantages, it also
comes with certain limitations. These limitations include a higher error rate
and the requirement of larger amounts of nucleic acid material compared to
other sequencing technologies like sequencing by synthesis (SBS).
Researchers are actively working on substantial improvements to reduce
the error rate and ensure high data accuracy. These efforts involve optimizing
molecule translocation ratcheting, achieving context-independent and
high-quality raw signals, and developing base-calling methods using advanced
computational techniques like machine learning.
Currently, nanopore sequencing requires a few micrograms of DNA and
hundreds of nanograms of RNA, which can be an experimental barrier. Reducing
the sample size requirement would greatly benefit nanopore sequencing in
various biomedical studies where genetic material is limited. Additionally,
integrating and automating DNA/RNA extraction, library preparation, and loading
systems would be highly beneficial for generating sequencing data without the
need for specific training. The development of robust bioinformatics software
that enables cloud storage, computing, and real-time analysis will further
drive the adoption of nanopore sequencing across different applications and
settings.
Despite the experimental challenges, the nanopore sequencing market is
expected to grow significantly due to rapid advancements in this technology.
Ongoing improvements in terms of read length, throughput, and accuracy aim to
facilitate research and clinical applications such as rapid clinical diagnosis
and outbreak surveillance.
Issues In Maintaining the Integration and Structure of The Nucleotide
Issues in maintaining the integration and structure of nucleotides are
posing challenges that may potentially impact the demand for nanopore
sequencing technology. While nanopore sequencing has shown immense promise in
various genomics applications, it is not without limitations, and certain
challenges associated with the preservation of nucleotide integrity are worth
considering. Nanopore sequencing requires intact DNA or RNA molecules to pass
through the nanopores for accurate sequencing. However, biological samples,
especially those from older or degraded specimens, can suffer from DNA damage
and fragmentation. Maintaining the structural integrity of nucleotides becomes
critical in such cases, as damaged or fragmented molecules can lead to
sequencing errors and reduced data quality.
Nucleotide modifications, such as methylation or hydroxymethylation,
play crucial roles in gene regulation and epigenetics. Nanopore sequencing has
the potential to detect these modifications directly, but maintaining the
structural integrity of nucleotides during sequencing is essential for
preserving this valuable epigenetic information accurately. Ongoing research
and development efforts are addressing many of the issues related to
maintaining nucleotide integrity in nanopore sequencing. Improved library
preparation protocols, enhanced nanopore chemistry, and software advancements
are gradually mitigating some of these concerns. However, it is essential for
users to carefully assess their specific research needs and the quality of
their nucleotide samples when considering the adoption of nanopore sequencing
technology, particularly in applications where nucleotide structure is critical
to the research outcome.
Key Market Trends
Use Of Nanopore sequencing for Fourth Generation DNA Sequencing
The surge in the use of nanopore sequencing for fourth-generation DNA
sequencing is anticipated to offer a highly lucrative opportunity for market
growth in the coming years. Nanopore-based sequencers, as the fourth-generation
DNA sequencing technology, have shown tremendous potential in quickly and
reliably sequencing the entire human genome for less than USD 1000, and
possibly even less than USD 100. This significant decrease in the cost of nanopore
sequencing for analyzing different types of sequences is expected to capture
the attention of a majority of healthcare professionals, including researchers,
clinicians, and geneticists. With the ability to provide fast and accurate DNA
sequencing results at a fraction of the cost of traditional methods, nanopore
sequencing have the potential to revolutionize the field of genomics. This
advancement will not only make DNA sequencing more accessible and affordable
for a wider range of applications but also enable new discoveries and
advancements in personalized medicine, genetic research, and disease diagnosis.
The integration of nanopore sequencing into healthcare settings has the
potential to transform the way we understand and treat genetic diseases, paving
the way for more targeted and effective therapies. As the adoption of
nanopore-based sequencers continues to grow, the market is poised for significant
expansion, presenting exciting opportunities for companies operating in the
genomics and biotechnology sectors.
Miniaturization and Portability
Nanopore sequencers will continue to become smaller and more portable.
Handheld or field-deployable devices will enable on-site sequencing in remote
locations, disaster response scenarios, and point-of-care applications. Researchers
and engineers are working to reduce the size and weight of nanopore sequencing
devices. This involves shrinking the electronics, improving heat management,
and optimizing power consumption to create more compact instruments. Field-deployable
devices need to withstand harsh conditions, including temperature variations,
humidity, and physical shocks. Robust construction and ruggedized designs will
be essential to ensure the reliability of these devices.
Simplified sample preparation techniques will be designed to minimize
the need for extensive laboratory equipment and expertise. These techniques
will be tailored to the unique requirements of portable nanopore sequencers. Handheld
sequencers will be part of a broader ecosystem that includes field laboratories
equipped with portable DNA extraction and sample preparation systems. This
integration ensures a seamless workflow from sample collection to sequencing in
remote locations. Portable nanopore sequencers will be designed with specific
field applications in mind, such as monitoring infectious disease outbreaks,
studying environmental microbiomes, or performing rapid diagnostics in
point-of-care settings.
Segmental Insights
Product Insights
Based on the
comprehensive product analysis, it is evident that the consumables segment is
the primary contributor to revenue and is projected to experience substantial
growth throughout the entire forecast period. This can be attributed to the
notable surge in the utilization of consumables across a wide range of
procedures, including DNA sequencing and RNA sequencing, which are crucial in
advancing scientific research and innovation in the field of genomics.
Furthermore, the
rising adoption of consumables in previously unexplored applications, such as
the sequencing of novel viruses, is expected to further bolster the segment's
market share. This expansion into new territories highlights the adaptability
and versatility of consumables, showcasing their vital role in addressing
emerging challenges and exploring new frontiers in genomics. As the demand for
advanced genetic analysis continues to increase, the significance of
consumables cannot be overstated. They serve as the backbone of scientific
advancements, facilitating breakthrough discoveries and enabling researchers to
unravel the complexities of the genetic code. With their pivotal role in
enhancing the accuracy, efficiency, and reliability of genomics research,
consumables are poised to shape the future of scientific exploration and
contribute to the ongoing progress in the field.
End User Insights
Based on end user,
the global market was predominantly led by Academic & Research Institutes,
a trend that is expected to continue in the foreseeable future. This dominance
can be attributed to the surging demand for nanopore sequencing in research
institutes, which are increasingly recognized for their immense potential to
revolutionize various fields of study. The adoption of nanopore sequencing by
these institutes has not only facilitated ground-breaking research but has also
paved the way for remarkable discoveries, further solidifying their position as
key drivers of innovation in the market. With their unwavering commitment to
pushing the boundaries of scientific exploration, Academic & Research
Institutes are poised to shape the future of technological advancements and
continue to fuel the progress of the market.
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Regional Insights
North America is well-positioned to dominate the market during the
forecast period. This is primarily due to the increasing demand for nanopore
sequencing, driven by the rising incidences of viral diseases in the region.
Moreover, the presence of major key players in North America further
strengthens its market position. Additionally, the growing targeted patient
population and higher healthcare expenditure contribute to the region's market
growth. The favorable government policies for research in nanopore sequencing
also act as a catalyst for market expansion in the coming years.
Furthermore, Asia-Pacific, South America, and the Middle East and Africa
(MEA) present lucrative opportunities for key players in the nanopore
technology market. The increasing number of hospitals equipped with nanopore
technology modalities and the significant utilization of nanopore sequencing in
these regions contribute to their market potential. Moreover, the market is
anticipated to witness growth in the next few years, fueled by the rising
geriatric population, which is more susceptible to viral diseases.
The market outlook for nanopore sequencing is promising, with North
America leading the way and other regions offering significant growth
opportunities. The combination of increasing demand, favorable government
policies, and the rising geriatric population sets the stage for continued
market expansion in the coming years.
Recent Developments
- In April 2022,
Oxford Nanopore Technologies partnered with Genomics England to assess the
advantages of sequencing in enhancing patient care and advancing research
efforts for the development of innovative treatments on a larger scale,
utilizing nanopore sequencing technology.
- In January 2021,
Oxford Nanopore Technologies collaborated with NVIDIA to integrate NVIDIA DGX
Station A100 into PromethION, Oxford Nanopore's high-throughput sequencing
platform, with the objective of delivering a robust sequencer that provides
real-time analysis capabilities.
- In May 2020, F.
Hoffmann-La Roche Ltd acquired Stratos Genomics, a US-based fourth-generation
genetic sequencing company, to drive the advancement of nanopore sequencers for
diagnostic applications by combining electronics and biological components.
Key Market Players
- Oxford Nanopore Technologies plc
- Illumnia, Inc.
- F. Hoffmann-La Roche AG
- 10X Genomics, Inc.
- Agilent Technolgies, Inc.
- NabSys, Inc.
- Sequenom, Inc.
- Quantapore, Inc.
- InanoBio Inc.
- Electronic BioSciences, Inc.
|
By Product
|
By Nucleotide Sequenced
|
By Type
|
By Type of Nanopore
|
By Application
|
By End User
|
By Region
|
|
|
|
|
- Direct Current Sequencing
- Synthetic DNA and Horizontal Tunnelling Current
Sequencing
- Optical Reading Techniques Sequencing
- Exonuclease Sequencing
|
- Solid State
- Biological
- Hybrid
|
- Human Genetics
- Clinical Research
- Plant Research
- Microbiology
- Animal Research
|
- Biotechnology Companies
- Clinical Laboratories
- Academic & Research Institutes
|
- North America
- Europe
- Asia Pacific
- South America
- Middle East & Africa
|
Report Scope:
In this report, the Global Nanopore Sequencing Market has been segmented
into the following categories, in addition to the industry trends which have
also been detailed below:
- Nanopore Sequencing Market, By Product:
o
Consumables
o
Instruments
- Nanopore Sequencing Market, By Nucleotide Sequenced:
o
DNA
o
RNA
- Nanopore Sequencing Market, By Type:
o
Direct Current Sequencing
o
Synthetic DNA and Horizontal Tunnelling Current
Sequencing
o
Optical Reading Techniques Sequencing
o
Exonuclease Sequencing
- Nanopore Sequencing Market, By Type of Nanopore:
o
Solid State
o
Biological
o
Hybrid
- Nanopore Sequencing Market, By Type of Application:
o
Human Genetics
o
Clinical Research
o
Plant Research
o
Microbiology
o
Animal Research
- Nanopore Sequencing Market, By Type of End User:
o
Biotechnology Companies
o
Clinical Laboratories
o
Academic & Research Institutes
- Nanopore Sequencing Market, By Region:
o North America
§ United States
§ Canada
§ Mexico
o Europe
§ France
§ United Kingdom
§ Italy
§ Germany
§ Spain
o Asia-Pacific
§ China
§ India
§ Japan
§ Australia
§ South Korea
o South America
§ Brazil
§ Argentina
§ Colombia
o Middle East & Africa
§ South Africa
§ Saudi Arabia
§ UAE
§ Kuwait
§ Turkey
§ Egypt
Competitive Landscape
Company Profiles: Detailed
analysis of the major companies present in the Global Nanopore Sequencing Market.
Available Customizations:
Global Nanopore Sequencing market report with the given market
data, Tech Sci Research offers customizations according to a company's specific
needs. The following customization options are available for the report:
Company Information
- Detailed analysis and profiling of
additional market players (up to five).
Global Nanopore Sequencing Market is an upcoming report to be released
soon. If you wish an early delivery of this report or want to confirm the date
of release, please contact us at [email protected]