Bone Cement and Glue Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Type (Bone Cement (Polymethyl Methacrylate (PMMA) Cement, Calcium Phosphate Cement (CPC) and Glass Polyalkenoate Cement (GPC)), Bone glue (Natural Bone Glue and Synthetic Bone Glue)), By Application (Arthroplasty, Total Knee Arthroplasty, Total Hip Arthroplasty, Total Shoulder Arthroplasty, Kyphoplasty, Vertebroplasty), By End User (Hospitals & Clinics, Ambulatory Care Centers, Others), By Region and Competition, 2020-2030F

Market Overview

The Global Bone Cement and Glue Market, valued at USD 2.48 Billion in 2024, is projected to experience a CAGR of 5.93% to reach USD 3.51 Billion by 2030. Bone cement and glue constitute a category of specialized biomaterials primarily employed in orthopedic surgical interventions for the stable fixation, structural augmentation, or comprehensive reconstruction of bone. The market's growth is fundamentally propelled by a global demographic shift towards an aging population and a rising incidence of orthopedic ailments, particularly osteoporosis and various musculoskeletal conditions. According to the International Osteoporosis Foundation, up to 37 million fragility fractures occur annually worldwide in individuals aged over 55, as reported in October 2024. This substantial prevalence directly underpins the demand for effective bone repair solutions.

Further market drivers include ongoing advancements in surgical techniques and an increasing global volume of joint replacement procedures. However, a notable challenge that could impede sustained market expansion involves the inherent complexities associated with ensuring optimal long-term implant performance and effectively mitigating potential post-operative complications, such as infection or aseptic loosening, which necessitates continuous innovation and stringent clinical validation within the industry.

Key Market Drivers

The Global Bone Cement and Glue Market is significantly influenced by an aging global population and the increasing incidence of orthopedic disorders. The demographic shift towards an older populace inherently increases the pool of potential patients requiring orthopedic interventions. As individuals age, they become more susceptible to degenerative conditions impacting bones and joints, elevating the demand for bone cement and glue in surgical procedures. According to the World Health Organization, in February 2025, "Ageing: Global population", the number of people aged 60 and older worldwide is projected to increase from 1.1 billion in 2023 to 1.4 billion by 2030. This expanding elderly demographic directly contributes to a higher prevalence of orthopedic conditions. Concurrently, the rising incidence of various orthopedic disorders, such as osteoarthritis and trauma, further amplifies the need for effective bone fixation and augmentation solutions. These conditions often require surgical procedures where bone cement and glue are integral. According to Frontiers, in November 2024, "Global, regional, and national burdens of osteoarthritis from 1990 to 2021", the global prevalence of osteoarthritis reached approximately 606.9 million cases in 2021. This substantial and growing burden directly underpins the sustained demand for bone cement and glue technologies.

This demand for orthopedic solutions is reflected in the broader industry performance. According to BONEZONE, in May 2025, "State of the Orthopedic Industry", global orthopedic sales totaled $61.9 billion in 2024, representing a 5% growth from the previous year. This market expansion underscores the critical role of specialized biomaterials like bone cement and glue in addressing the evolving orthopedic healthcare needs worldwide.

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Key Market Challenges

The inherent complexities associated with ensuring optimal long-term implant performance and effectively mitigating potential post-operative complications, such as aseptic loosening, present a significant impediment to the growth of the Global Bone Cement and Glue Market. The challenge lies in developing biomaterials that consistently maintain stable fixation over extended periods within dynamic biological environments. Failures in this regard lead to revision surgeries, which are resource-intensive, costly, and expose patients to additional risks, thereby impacting the perceived reliability and widespread adoption of bone cement solutions.

Aseptic loosening, a prevalent complication where the mechanical bond between the implant and bone cement fails without evidence of infection, directly restricts market expansion. According to a systematic review and meta-analysis published in PubMed Central in May 2023, the collective aseptic loosening rate in revision total hip arthroplasty femoral components was reported at 5.8%. Such rates necessitate complex and expensive re-operations, diminishing patient satisfaction and placing a greater burden on healthcare systems. This persistent risk factor contributes to a cautious approach among orthopedic surgeons, potentially limiting the broader application of bone cement and glue, and influencing the consideration of alternative fixation methods in situations where long-term stability is critical.

Key Market Trends

The Global Bone Cement and Glue Market is significantly shaped by the integration of antibiotic-loaded formulations, addressing the critical challenge of post-operative infections. These specialized cements and glues deliver localized antibiotic concentrations directly at the surgical site, aiming to mitigate bacterial colonization and reduce the risk of surgical site infections, which can lead to severe complications and increased healthcare costs. According to Knee Surgery, Sports Traumatology, Arthroscopy, in 2024, antibiotic-loaded bone cement demonstrated a protective effect against infection with a Hazard Ratio of 0.53 following total knee arthroplasty, contributing to higher prosthetic survival. This focused approach enhances patient safety and improves long-term implant success rates, thereby driving adoption across various orthopedic procedures.

Another influential trend is the widespread adoption of 3D printing in manufacturing processes for bone cement and glue. This technological advancement enables the production of highly customized and patient-specific implants and prostheses, offering superior anatomical fit and potentially improved biomechanical performance. The precision and design flexibility afforded by 3D printing allow for complex structures that can better mimic natural bone architecture or integrate specific features for enhanced healing. According to BONEZONE, in May 2025, orthopedic applications were one of the most dynamic segments of healthcare additive manufacturing, exhibiting almost 20% growth per year, reflecting the increasing demand for personalized solutions in orthopedic care. This manufacturing paradigm shift not only optimizes surgical outcomes but also streamlines production workflows, making personalized solutions more accessible.

Segmental Insights

The Bone Cement segment is currently experiencing the most rapid expansion within the Global Bone Cement and Glue Market. This growth is primarily fueled by an escalating global aging demographic, which directly contributes to a higher incidence of age-related orthopedic conditions such as osteoarthritis and osteoporosis. Consequently, there is a surge in demand for orthopedic procedures, including joint replacement surgeries for hips and knees, alongside spinal interventions, which critically rely on bone cement for implant stability and patient outcomes. Furthermore, ongoing advancements in bone cement formulations, enhancing properties like strength, durability, and biocompatibility, are significantly contributing to its accelerated adoption across various clinical applications.

Regional Insights

North America holds the leading position in the global bone cement and glue market due to its highly developed healthcare infrastructure and substantial healthcare expenditures. The region experiences a significant prevalence of orthopedic conditions, including arthritis and fractures, coupled with an aging population, driving consistent demand for relevant surgical procedures. Furthermore, favorable reimbursement policies contribute to increased access to advanced treatments. The presence of a robust regulatory framework, exemplified by bodies like the U. S. Food and Drug Administration, ensures the introduction of high-quality, reliable products. This environment fosters innovation and supports the strong presence of major medical device manufacturers.

Recent Developments

• In September 2025, a research team in China achieved a significant breakthrough with the development of "Bone-02," a novel bone glue capable of repairing fractures in approximately three minutes. Inspired by the strong adhesive properties of oysters, this biodegradable bio-adhesive has undergone successful testing on over 150 patients. Bone-02 demonstrated a bonding force exceeding 400 pounds and a compressive strength around 10 MPa, indicating its potential to replace traditional metal plates and screws. This innovation could revolutionize orthopedic surgery by offering faster fixation, reducing the need for repeat surgeries, and minimizing risks associated with conventional implants in the Global Bone Cement and Glue Market.

• In February 2025, the Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) launched two innovative drug-eluting bone graft products, BONYX and CASPRO. These products are manufactured and marketed by Onyx Medicals Pvt. Ltd. BONYX comprises bioceramic beads for local drug delivery in bone, primarily for treating infections. CASPRO is a bioactive, mouldable, and self-setting bone cement designed for drug delivery, capable of controlled drug release for over 21 days while promoting bone regeneration by integrating with native bone tissues. This launch introduces advanced solutions for bone infection treatment and fracture healing in the Global Bone Cement and Glue Market.

• In August 2024, Heraeus Medical USA announced the U.S. Food & Drug Administration clearance for its COPAL G+V dual antibiotic-loaded bone cement. The company subsequently introduced this high-viscosity bone cement, containing gentamicin and vancomycin, to the orthopedic community in December 2024. Designed specifically for periprosthetic joint infection (PJI) management, COPAL G+V offers high local antibiotic elution at the surgical site while maintaining low systemic exposure for the patient. This product represents an important advancement in addressing the challenges of infections in joint replacement surgeries within the Global Bone Cement and Glue Market.

• In January 2024, Biomimetic Innovations, an affiliate of PBC Biomed, received the U.S. Food and Drug Administration (FDA) Breakthrough Device designation for its OsStic bone tissue glue. This injectable bioadhesive is engineered to provide structural stability for joint fractures and defects where standard fixation methods may be insufficient. The Breakthrough Device designation aims to expedite the development, assessment, and review process for OsStic, facilitating timely patient and healthcare provider access to this promising medical device. This recognition underscores its potential as a superior treatment option in the Global Bone Cement and Glue Market.

Key Market Players

• 3M Company
• BSN medical (Aust.) Pty Ltd
• Stryker Corporation
• Zimmer Biomet Holdings, Inc.
• Smith+Nephew PLC
• DJO, LLC
• India Medtronic Private Limited
• Globus Medical, Inc.
• Johnson & Johnson Services, Inc.
• Arthrex Inc.

Report Scope:

In this report, the Global Bone Cement and Glue Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

• Bone Cement and Glue Market, By Type:

o   Bone Cement

o   Bone Glue

• Bone Cement and Glue Market, By Application:

o   Arthroplasty

o   Total knee arthroplasty

o   Total hip arthroplasty

o   Total shoulder arthroplasty

o   Kyphoplasty

o   Vertebroplasty

• Bone Cement and Glue Market, By End User:

o   Hospitals & Clinics

o   Ambulatory Care Centers

o   Others

• Bone Cement and Glue Market, By Region:

o   North America

§  United States

§  Canada

§  Mexico

o   Europe

§  France

§  United Kingdom

§  Italy

§  Germany

§  Spain

o   Asia Pacific

§  China

§  India

§  Japan

§  Australia

§  South Korea

o   South America

§  Brazil

§  Argentina

§  Colombia

o   Middle East & Africa

§  South Africa

§  Saudi Arabia

§  UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies presents in the Global Bone Cement and Glue Market.

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Company Information

• Detailed analysis and profiling of additional market players (up to five).

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