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Report Description

Report Description

Forecast Period

2027-2031

Market Size (2025)

USD 19.11 Billion

CAGR (2026-2031)

3.77%

Fastest Growing Segment

Medication

Largest Market

North America

Market Size (2031)

USD 23.86 Billion

Market Overview

The Global Atherosclerosis Drugs Market will grow from USD 19.11 Billion in 2025 to USD 23.86 Billion by 2031 at a 3.77% CAGR. Atherosclerosis drugs are pharmaceutical agents formulated to mitigate arterial plaque accumulation, primarily by regulating lipid levels and inhibiting thrombus formation to prevent cardiovascular events. The market is fundamentally driven by the escalating global burden of cardiovascular conditions and an aging demographic susceptible to arterial hardening. According to the American Heart Association, in 2024, it was reported that cardiovascular diseases accounted for approximately 19.91 million global deaths annually. This substantial prevalence underscores the critical necessity for continuous pharmacological intervention and sustains the demand for therapeutic, plaque-stabilizing regimens.

However, the market encounters a significant impediment regarding the patent expiration of key blockbuster therapies. The subsequent entry of cost-effective generic alternatives significantly erodes the market share and revenue streams of established branded drugs. Consequently, pharmaceutical developers face increased pressure to innovate, yet high development costs and rigorous regulatory frameworks often delay the commercialization of next-generation atherosclerosis treatments.

Key Market Drivers

The rising global prevalence of cardiovascular diseases and hyperlipidemia stands as the primary catalyst propelling the atherosclerosis drugs market. As sedentary lifestyles and poor dietary habits become more ubiquitous, the incidence of arterial plaque deposition and lipid abnormalities has intensified, creating a substantial patient pool necessitating pharmacological management. This expanding disease burden directly correlates with increased demand for lipid-lowering therapies, such as statins and combination agents, to prevent critical events like myocardial infarctions and strokes. According to the American Heart Association, January 2024, in the '2024 Heart Disease and Stroke Statistics Update', approximately 127.9 million adults in the United States had some form of cardiovascular disease between 2017 and 2020. Such widespread prevalence compels healthcare providers to aggressively prescribe pharmaceutical interventions, thereby sustaining consistent revenue growth for manufacturers.

Simultaneously, advancements in novel therapeutics and the robust development of PCSK9 inhibitors are reshaping the treatment landscape for atherosclerosis. Pharmaceutical companies are actively investing in research and development to introduce next-generation biologics and oral therapies for patients who are intolerant to traditional statins or require additional lipid reduction. For instance, according to NewAmsterdam Pharma, July 2024, in the 'Phase 3 BROOKLYN Clinical Trial Results', the novel CETP inhibitor obicetrapib achieved a 36.3% reduction in low-density lipoprotein cholesterol at day 84 compared to placebo. The commercial viability of these advanced treatments is evident in the market's performance; according to Amgen, October 2024, in the 'Third Quarter 2024 Financial Results', sales for the PCSK9 inhibitor Repatha increased 40% year-over-year to $567 million. These innovations not only offer superior efficacy but also drive market value by addressing unmet medical needs in high-risk patient populations.

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Key Market Challenges

The patent expiration of key blockbuster therapies acts as a formidable barrier to the financial expansion of the Global Atherosclerosis Drugs Market. As exclusivity periods conclude for major lipid-regulating and antithrombotic agents, the sector faces an immediate influx of generic competitors priced significantly lower than their branded counterparts. This transition precipitates a sharp reduction in market valuation, as the high revenues associated with exclusive proprietary drugs are replaced by the high-volume, low-margin economics of generic formulations. Consequently, pharmaceutical originators experience a rapid erosion of revenue streams, which dampens the sector's aggregate monetary growth and restricts the capital available for reinvestment into high-risk research programs.

The scale of this financial impact is substantial and quantifiable. According to the Association for Accessible Medicines, in 2024, it was reported that generic medicines generated $118.1 billion in savings for patients with heart disease during the preceding year. This figure effectively represents the massive volume of value diverted away from the branded pharmaceutical market. Such widespread adoption of cost-effective alternatives suppresses the overall revenue potential of the market, making it difficult for the industry to sustain previous growth trajectories relying solely on established product lines.

Key Market Trends

The label expansion of Glucagon-Like Peptide-1 agonists for cardiovascular prevention represents a transformative trend in the atherosclerosis drugs market. While originally indicated for diabetes and weight management, these therapeutics are increasingly utilized to mitigate the risk of major adverse cardiovascular events in patients with established atherosclerotic cardiovascular disease. This shift acknowledges the systemic metabolic factors that exacerbate arterial plaque instability, moving beyond simple lipid management to address broader inflammatory and metabolic risks. Supporting this therapeutic evolution, according to Novo Nordisk, March 2024, in the press release 'Wegovy approved in the US for cardiovascular risk reduction in people with overweight or obesity', clinical trials demonstrated that semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% in adults with known cardiovascular disease and overweight or obesity.

Simultaneously, the development of targeted therapies specifically designed to lower Lipoprotein(a) is addressing a critical unmet need in precision medicine. Elevated Lipoprotein(a) is a genetically determined risk factor that contributes to atherosclerosis independently of low-density lipoprotein cholesterol and remains largely unresponsive to traditional statin regimens. Pharmaceutical companies are leveraging advanced small interfering RNA technologies to silence the genes responsible for producing this atherogenic particle, thereby offering new hope for patients with high residual cardiovascular risk. Validating the potential of this mechanism, according to Silence Therapeutics, May 2024, in the 'Silence Therapeutics Announces Positive 36-Week Data from Phase 2 Study of Zerlasiran', the investigational drug zerlasiran achieved a median reduction in Lipoprotein(a) of 90% or greater at week 36 for patients in the two highest dosage cohorts.

Segmental Insights

The Medication segment currently represents the fastest-growing category within the Global Atherosclerosis Drugs Market, driven by a significant paradigm shift toward non-invasive pharmaceutical management of cardiovascular risks. This expansion is primarily fueled by the rising global burden of coronary artery disease and hyperlipidemia, which necessitates long-term pharmacological intervention to effectively control plaque accumulation. Additionally, the market benefits from the commercialization of novel therapeutic classes, such as PCSK9 inhibitors, following rigorous approvals from regulatory bodies like the U.S. Food and Drug Administration. These factors collectively underscore the increasing clinical reliance on pharmacotherapy for disease mitigation.

Regional Insights

North America maintains a dominant position in the global atherosclerosis drugs market, driven by a high prevalence of cardiovascular disorders and a well-established healthcare infrastructure. The region benefits from substantial research and development investments by major pharmaceutical companies focused on treating arterial plaque accumulation. Additionally, the U.S. Food and Drug Administration (FDA) plays a crucial role by facilitating the approval of novel therapies, ensuring timely patient access. Comprehensive insurance coverage and rising public awareness regarding heart health further consolidate North America's status as the leading regional market.

Recent Developments

  • In March 2025, Eli Lilly and Company presented positive results from the Phase 2 ALPACA clinical trial of lepodisiran at the American College of Cardiology Scientific Sessions. The data revealed that the investigational small interfering RNA therapy reduced levels of lipoprotein(a) by approximately 94% at the highest dose tested, with significant suppression maintained for nearly one year after treatment. This breakthrough research underscores the increasing innovation in the Global Atherosclerosis Drugs Market regarding genetic risk factors. The company noted that the deep and durable reductions observed could support an infrequent dosing regimen for patients with atherosclerotic cardiovascular disease.
  • In August 2024, NewAmsterdam Pharma Company announced positive topline results from the Phase 3 BROOKLYN clinical trial evaluating obicetrapib in patients with heterozygous familial hypercholesterolemia. The study met its primary endpoint, demonstrating that the novel oral CETP inhibitor achieved a statistically significant reduction in low-density lipoprotein cholesterol compared to placebo at day 84, with efficacy sustained over one year. These findings are critical for the Global Atherosclerosis Drugs Market, as they present a promising new oral, non-statin therapy for high-risk patients who remain unable to achieve their cholesterol targets despite using maximally tolerated lipid-lowering regimens.
  • In June 2024, Silence Therapeutics announced positive topline data from the 48-week analysis of its Phase 2 ALPACAR-360 study evaluating zerlasiran in patients with elevated cardiovascular risk. This short interfering RNA candidate is designed to lower lipoprotein(a), a genetically determined driver of atherosclerosis that is resistant to lifestyle changes and standard statin treatments. The results showed a highly significant and sustained reduction in lipoprotein(a) levels compared to placebo, reinforcing the drug's potential as a competitive entrant in the Global Atherosclerosis Drugs Market. The company confirmed that these findings supported the progression of zerlasiran into pivotal Phase 3 clinical development.
  • In March 2024, the U.S. Food and Drug Administration approved a significant label expansion for semaglutide, marketed by Novo Nordisk, to include the reduction of cardiovascular risks in adults with established cardiovascular disease and obesity or overweight. This regulatory milestone marked the first time a weight-management medication was authorized to prevent major adverse cardiovascular events, such as heart attacks and strokes, which are complications of atherosclerosis. The approval was based on the SELECT cardiovascular outcomes trial, which demonstrated a statistically significant reduction in cardiovascular events, thereby expanding therapeutic options in the Global Atherosclerosis Drugs Market beyond traditional lipid-lowering therapies.

Key Market Players

  • F. Hoffmann-La Roche Ltd
  • Novartis AG
  • Merck & Co. Inc.
  • Pfizer Inc.
  • Eli Lilly and Co.
  • Sanofi S.A.
  • AstraZeneca Plc
  • Bayer AG
  • Regeneron Pharmaceuticals Inc.
  • GSK Plc

By Diagnosis

By Treatment

By Route of Administration

By End User

By Region

  • Ankle-brachial Index
  • Doppler Ultrasound
  • Echocardiogram
  • Electrocardiogram
  • Blood Tests
  • Others
  • Medication
  • Surgery
  • Others
  • Oral
  • Parenteral
  • Others
  • Hospitals & Clinics
  • Ambulatory Care Centers
  • Others
  • North America
  • Europe
  • Asia Pacific
  • South America
  • Middle East & Africa

Report Scope:

In this report, the Global Atherosclerosis Drugs Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

  • Atherosclerosis Drugs Market, By Diagnosis:
  • Ankle-brachial Index
  • Doppler Ultrasound
  • Echocardiogram
  • Electrocardiogram
  • Blood Tests
  • Others
  • Atherosclerosis Drugs Market, By Treatment:
  • Medication
  • Surgery
  • Others
  • Atherosclerosis Drugs Market, By Route of Administration:
  • Oral
  • Parenteral
  • Others
  • Atherosclerosis Drugs Market, By End User:
  • Hospitals & Clinics
  • Ambulatory Care Centers
  • Others
  • Atherosclerosis Drugs Market, By Region:
  • North America
    • United States
    • Canada
    • Mexico
  • Europe
    • France
    • United Kingdom
    • Italy
    • Germany
    • Spain
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
  • South America
    • Brazil
    • Argentina
    • Colombia
  • Middle East & Africa
    • South Africa
    • Saudi Arabia
    • UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Atherosclerosis Drugs Market.

Available Customizations:

Global Atherosclerosis Drugs Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

Company Information

  • Detailed analysis and profiling of additional market players (up to five).

Global Atherosclerosis Drugs Market is an upcoming report to be released soon. If you wish an early delivery of this report or want to confirm the date of release, please contact us at [email protected]

Table of content

Table of content

1.    Product Overview

1.1.  Market Definition

1.2.  Scope of the Market

1.2.1.  Markets Covered

1.2.2.  Years Considered for Study

1.2.3.  Key Market Segmentations

2.    Research Methodology

2.1.  Objective of the Study

2.2.  Baseline Methodology

2.3.  Key Industry Partners

2.4.  Major Association and Secondary Sources

2.5.  Forecasting Methodology

2.6.  Data Triangulation & Validation

2.7.  Assumptions and Limitations

3.    Executive Summary

3.1.  Overview of the Market

3.2.  Overview of Key Market Segmentations

3.3.  Overview of Key Market Players

3.4.  Overview of Key Regions/Countries

3.5.  Overview of Market Drivers, Challenges, Trends

4.    Voice of Customer

5.    Global Atherosclerosis Drugs Market Outlook

5.1.  Market Size & Forecast

5.1.1.  By Value

5.2.  Market Share & Forecast

5.2.1.  By Diagnosis (Ankle-brachial Index, Doppler Ultrasound, Echocardiogram, Electrocardiogram, Blood Tests, Others)

5.2.2.  By Treatment (Medication, Surgery, Others)

5.2.3.  By Route of Administration (Oral, Parenteral, Others)

5.2.4.  By End User (Hospitals & Clinics, Ambulatory Care Centers, Others)

5.2.5.  By Region

5.2.6.  By Company (2025)

5.3.  Market Map

6.    North America Atherosclerosis Drugs Market Outlook

6.1.  Market Size & Forecast

6.1.1.  By Value

6.2.  Market Share & Forecast

6.2.1.  By Diagnosis

6.2.2.  By Treatment

6.2.3.  By Route of Administration

6.2.4.  By End User

6.2.5.  By Country

6.3.    North America: Country Analysis

6.3.1.    United States Atherosclerosis Drugs Market Outlook

6.3.1.1.  Market Size & Forecast

6.3.1.1.1.  By Value

6.3.1.2.  Market Share & Forecast

6.3.1.2.1.  By Diagnosis

6.3.1.2.2.  By Treatment

6.3.1.2.3.  By Route of Administration

6.3.1.2.4.  By End User

6.3.2.    Canada Atherosclerosis Drugs Market Outlook

6.3.2.1.  Market Size & Forecast

6.3.2.1.1.  By Value

6.3.2.2.  Market Share & Forecast

6.3.2.2.1.  By Diagnosis

6.3.2.2.2.  By Treatment

6.3.2.2.3.  By Route of Administration

6.3.2.2.4.  By End User

6.3.3.    Mexico Atherosclerosis Drugs Market Outlook

6.3.3.1.  Market Size & Forecast

6.3.3.1.1.  By Value

6.3.3.2.  Market Share & Forecast

6.3.3.2.1.  By Diagnosis

6.3.3.2.2.  By Treatment

6.3.3.2.3.  By Route of Administration

6.3.3.2.4.  By End User

7.    Europe Atherosclerosis Drugs Market Outlook

7.1.  Market Size & Forecast

7.1.1.  By Value

7.2.  Market Share & Forecast

7.2.1.  By Diagnosis

7.2.2.  By Treatment

7.2.3.  By Route of Administration

7.2.4.  By End User

7.2.5.  By Country

7.3.    Europe: Country Analysis

7.3.1.    Germany Atherosclerosis Drugs Market Outlook

7.3.1.1.  Market Size & Forecast

7.3.1.1.1.  By Value

7.3.1.2.  Market Share & Forecast

7.3.1.2.1.  By Diagnosis

7.3.1.2.2.  By Treatment

7.3.1.2.3.  By Route of Administration

7.3.1.2.4.  By End User

7.3.2.    France Atherosclerosis Drugs Market Outlook

7.3.2.1.  Market Size & Forecast

7.3.2.1.1.  By Value

7.3.2.2.  Market Share & Forecast

7.3.2.2.1.  By Diagnosis

7.3.2.2.2.  By Treatment

7.3.2.2.3.  By Route of Administration

7.3.2.2.4.  By End User

7.3.3.    United Kingdom Atherosclerosis Drugs Market Outlook

7.3.3.1.  Market Size & Forecast

7.3.3.1.1.  By Value

7.3.3.2.  Market Share & Forecast

7.3.3.2.1.  By Diagnosis

7.3.3.2.2.  By Treatment

7.3.3.2.3.  By Route of Administration

7.3.3.2.4.  By End User

7.3.4.    Italy Atherosclerosis Drugs Market Outlook

7.3.4.1.  Market Size & Forecast

7.3.4.1.1.  By Value

7.3.4.2.  Market Share & Forecast

7.3.4.2.1.  By Diagnosis

7.3.4.2.2.  By Treatment

7.3.4.2.3.  By Route of Administration

7.3.4.2.4.  By End User

7.3.5.    Spain Atherosclerosis Drugs Market Outlook

7.3.5.1.  Market Size & Forecast

7.3.5.1.1.  By Value

7.3.5.2.  Market Share & Forecast

7.3.5.2.1.  By Diagnosis

7.3.5.2.2.  By Treatment

7.3.5.2.3.  By Route of Administration

7.3.5.2.4.  By End User

8.    Asia Pacific Atherosclerosis Drugs Market Outlook

8.1.  Market Size & Forecast

8.1.1.  By Value

8.2.  Market Share & Forecast

8.2.1.  By Diagnosis

8.2.2.  By Treatment

8.2.3.  By Route of Administration

8.2.4.  By End User

8.2.5.  By Country

8.3.    Asia Pacific: Country Analysis

8.3.1.    China Atherosclerosis Drugs Market Outlook

8.3.1.1.  Market Size & Forecast

8.3.1.1.1.  By Value

8.3.1.2.  Market Share & Forecast

8.3.1.2.1.  By Diagnosis

8.3.1.2.2.  By Treatment

8.3.1.2.3.  By Route of Administration

8.3.1.2.4.  By End User

8.3.2.    India Atherosclerosis Drugs Market Outlook

8.3.2.1.  Market Size & Forecast

8.3.2.1.1.  By Value

8.3.2.2.  Market Share & Forecast

8.3.2.2.1.  By Diagnosis

8.3.2.2.2.  By Treatment

8.3.2.2.3.  By Route of Administration

8.3.2.2.4.  By End User

8.3.3.    Japan Atherosclerosis Drugs Market Outlook

8.3.3.1.  Market Size & Forecast

8.3.3.1.1.  By Value

8.3.3.2.  Market Share & Forecast

8.3.3.2.1.  By Diagnosis

8.3.3.2.2.  By Treatment

8.3.3.2.3.  By Route of Administration

8.3.3.2.4.  By End User

8.3.4.    South Korea Atherosclerosis Drugs Market Outlook

8.3.4.1.  Market Size & Forecast

8.3.4.1.1.  By Value

8.3.4.2.  Market Share & Forecast

8.3.4.2.1.  By Diagnosis

8.3.4.2.2.  By Treatment

8.3.4.2.3.  By Route of Administration

8.3.4.2.4.  By End User

8.3.5.    Australia Atherosclerosis Drugs Market Outlook

8.3.5.1.  Market Size & Forecast

8.3.5.1.1.  By Value

8.3.5.2.  Market Share & Forecast

8.3.5.2.1.  By Diagnosis

8.3.5.2.2.  By Treatment

8.3.5.2.3.  By Route of Administration

8.3.5.2.4.  By End User

9.    Middle East & Africa Atherosclerosis Drugs Market Outlook

9.1.  Market Size & Forecast

9.1.1.  By Value

9.2.  Market Share & Forecast

9.2.1.  By Diagnosis

9.2.2.  By Treatment

9.2.3.  By Route of Administration

9.2.4.  By End User

9.2.5.  By Country

9.3.    Middle East & Africa: Country Analysis

9.3.1.    Saudi Arabia Atherosclerosis Drugs Market Outlook

9.3.1.1.  Market Size & Forecast

9.3.1.1.1.  By Value

9.3.1.2.  Market Share & Forecast

9.3.1.2.1.  By Diagnosis

9.3.1.2.2.  By Treatment

9.3.1.2.3.  By Route of Administration

9.3.1.2.4.  By End User

9.3.2.    UAE Atherosclerosis Drugs Market Outlook

9.3.2.1.  Market Size & Forecast

9.3.2.1.1.  By Value

9.3.2.2.  Market Share & Forecast

9.3.2.2.1.  By Diagnosis

9.3.2.2.2.  By Treatment

9.3.2.2.3.  By Route of Administration

9.3.2.2.4.  By End User

9.3.3.    South Africa Atherosclerosis Drugs Market Outlook

9.3.3.1.  Market Size & Forecast

9.3.3.1.1.  By Value

9.3.3.2.  Market Share & Forecast

9.3.3.2.1.  By Diagnosis

9.3.3.2.2.  By Treatment

9.3.3.2.3.  By Route of Administration

9.3.3.2.4.  By End User

10.    South America Atherosclerosis Drugs Market Outlook

10.1.  Market Size & Forecast

10.1.1.  By Value

10.2.  Market Share & Forecast

10.2.1.  By Diagnosis

10.2.2.  By Treatment

10.2.3.  By Route of Administration

10.2.4.  By End User

10.2.5.  By Country

10.3.    South America: Country Analysis

10.3.1.    Brazil Atherosclerosis Drugs Market Outlook

10.3.1.1.  Market Size & Forecast

10.3.1.1.1.  By Value

10.3.1.2.  Market Share & Forecast

10.3.1.2.1.  By Diagnosis

10.3.1.2.2.  By Treatment

10.3.1.2.3.  By Route of Administration

10.3.1.2.4.  By End User

10.3.2.    Colombia Atherosclerosis Drugs Market Outlook

10.3.2.1.  Market Size & Forecast

10.3.2.1.1.  By Value

10.3.2.2.  Market Share & Forecast

10.3.2.2.1.  By Diagnosis

10.3.2.2.2.  By Treatment

10.3.2.2.3.  By Route of Administration

10.3.2.2.4.  By End User

10.3.3.    Argentina Atherosclerosis Drugs Market Outlook

10.3.3.1.  Market Size & Forecast

10.3.3.1.1.  By Value

10.3.3.2.  Market Share & Forecast

10.3.3.2.1.  By Diagnosis

10.3.3.2.2.  By Treatment

10.3.3.2.3.  By Route of Administration

10.3.3.2.4.  By End User

11.    Market Dynamics

11.1.  Drivers

11.2.  Challenges

12.    Market Trends & Developments

12.1.  Merger & Acquisition (If Any)

12.2.  Product Launches (If Any)

12.3.  Recent Developments

13.    Global Atherosclerosis Drugs Market: SWOT Analysis

14.    Porter's Five Forces Analysis

14.1.  Competition in the Industry

14.2.  Potential of New Entrants

14.3.  Power of Suppliers

14.4.  Power of Customers

14.5.  Threat of Substitute Products

15.    Competitive Landscape

15.1.  F. Hoffmann-La Roche Ltd

15.1.1.  Business Overview

15.1.2.  Products & Services

15.1.3.  Recent Developments

15.1.4.  Key Personnel

15.1.5.  SWOT Analysis

15.2.  Novartis AG

15.3.  Merck & Co. Inc.

15.4.  Pfizer Inc.

15.5.  Eli Lilly and Co.

15.6.  Sanofi S.A.

15.7.  AstraZeneca Plc

15.8.  Bayer AG

15.9.  Regeneron Pharmaceuticals Inc.

15.10.  GSK Plc

16.    Strategic Recommendations

17.    About Us & Disclaimer

Figures and Tables

Frequently asked questions

Frequently asked questions

The market size of the Global Atherosclerosis Drugs Market was estimated to be USD 19.11 Billion in 2025.

North America is the dominating region in the Global Atherosclerosis Drugs Market.

Medication segment is the fastest growing segment in the Global Atherosclerosis Drugs Market.

The Global Atherosclerosis Drugs Market is expected to grow at 3.77% between 2026 to 2031.

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