Ligase Market to Grow with a CAGR of 6.16% through 2030
Growing R&D activities
and growing need for disease treatment to drive the ligase market in the
forecast period, 2026-2030.
According to TechSci Research report, “Ligase
Market
- Global Industry Size, Share, Trends, Opportunity, and Forecast, 2030”, the Global Ligase Market was valued at USD 471.00 million in 2024 and is expected to reach USD 674.19 million by 2030 with a CAGR of 6.16% during the forecast period. The rising incidence of infectious,
genetic, and chronic diseases, and extensive research and development are the
primary factors driving the demand for the global ligase market. Growing adoption
of advanced technology, expansion of diagnostics and pharmaceutical companies,
rise in world population, growing research & development, expansion of
biopharmaceutical industries and biopharma production, growing need of ligase
in disease treatment and heavy investments in healthcare sector are expected to
influence the market demand. Also, increasing strategic growth is also a key
factor for increasing the growth of the ligase market, globally.
However, the have minimal activity on short cohesive
and blunt substrates in end-joining reactions, and certain NAD-dependent
thermostable DNA ligase, which is used in vitro, can ligate only inadequate
number of nicks may hamper the growth of the global ligase market.
Browse over XX market
data Figures spread through XX Pages and an in-depth TOC on "Global Ligase Market"
The global ligase market is
segmented into product, source, application, end user, regional distribution and company.
Based on Source, the Thermus thermophilus (Tth) source category shows the fastest growth. This trend is driven by the increasing demand for thermostable ligases in advanced molecular biology and diagnostics applications, particularly in polymerase chain reaction (PCR)-based techniques, next-generation sequencing (NGS), and single nucleotide polymorphism (SNP) detection assays. Unlike ligases derived from Escherichia coli or other mesophilic organisms, Tth DNA ligase is capable of functioning efficiently at elevated temperatures. This unique property makes it highly suitable for ligation chain reaction (LCR) and other temperature-cycling applications where stable enzyme performance is required. For example, in molecular diagnostics, thermostable ligases are essential for detecting subtle genetic variations linked to hereditary diseases and cancer. With the rise in genomic-based diagnostics, particularly in oncology, the adoption of Tth ligase is accelerating.
Based on the Region, the Asia Pacific region shows the fastest growth, driven by rapid expansion in biotechnology research, increasing healthcare investments, and rising demand for molecular diagnostics. Countries such as China, India, Japan, and South Korea are at the forefront of this growth, supported by strong government initiatives to strengthen life sciences and genomic research. For example, China’s 14th Five-Year Plan for Biotechnology Development emphasizes advancements in genetic engineering, synthetic biology, and precision medicine—all of which require ligases as essential tools for DNA ligation and cloning applications. Similarly, India’s Department of Biotechnology (DBT) has invested heavily in genomics programs, such as the Genome India Project, which aims to sequence thousands of Indian genomes and relies on enzymatic technologies including ligases.
Major companies operating
in Global Ligase Market are:
- Bio-Rad Laboratories, Inc.
- Agilent Technologies, Inc.
- Codexis, Inc.
- F. Hoffmann-La Roche AG
- Merck KGaA
- Promega Corporation
- QIAGEN N.V.
- ArcticZymes Technologies ASA
- Thermo Fisher Scientific, Inc.
- Takara Bio Inc.
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“North America region dominates the
market and is expected to maintain its dominance in the coming years
due to the high occurrence of genetic defects and a rise in the number of
individuals needing long-term care in the region. Increase in investments for
R&D to promote the production of ligases as therapeutics for various,
presence of many leading players, the
well-established end-user industries, and extensive advancements in technology,
in the region is another key factor. Also,
the high number of firms with a strategic pipeline in the region are expected
to propel the global ligase market growth” said Mr. Karan Chechi,
Research Director of TechSci Research, a research based global management
consulting firm.
“Ligase Market - Global
Industry Size, Share, Trends, Opportunity, and Forecast, Segmented
By Product (Quick Ligase, T4 DNA Ligase,
E.Coli DNA Ligase, T4 RNA Ligase, Others), By Source (Archaebacterium,
Escherichia coli, Thermus thermophilus, Others), By Application (Ligase Chain
Reaction, Ligase Detection Reaction, Next Generation Sequencing, Molecular
Cloning, Others), By End User (Biotechnology & Pharmaceutical Companies,
Academic & Research Institutions, Others), By Region and Competition, 2020-2030F”, has evaluated the future growth potential of global ligase
market and provides statistics & information on market size, structure, and
future market growth. The report intends to provide cutting-edge market
intelligence and help decision makers take sound investment decisions. Besides,
the report also identifies and analyzes the emerging trends along with
essential drivers, challenges, and opportunities in global ligase market.
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