Press Release

Heart Failure Therapeutics Market to Grow with a CAGR of 6.39% through 2031

Expanding healthcare infrastructure, regulatory support, and collaborative efforts are expected to drive growth in the Global Heart Failure Therapeutics Market over the forecast period, 2027-2031.


According to TechSci Research report, “Heart Failure Therapeutics Market – Global Industry Size, Share, Trends, Competition Forecast & Opportunities, 2021-2031F”, the Global Heart Failure Therapeutics Market will grow from USD 8.47 Billion in 2025 to USD 12.28 Billion by 2031 at a 6.39% CAGR. This can be attributed to collaboration and partnerships. Collaboration between pharmaceutical companies, healthcare providers, academic institutions, and research organizations is fostering innovation. These partnerships facilitate the sharing of knowledge, expertise, and resources, accelerating the development of new therapies and treatment approaches.

Furthermore, gene and cell therapies hold promise for treating heart failure by addressing its underlying causes. Research in this area is advancing, with the potential for groundbreaking treatments in the near future.      


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The market is experiencing growth driven by several key factors, including a robust product pipeline, a growing elderly population, and increased research and development efforts in drug development. Another significant factor contributing to this growth is the increasing prevalence of diseases such as obesity, diabetes, hypertension, chronic pulmonary diseases, and renal diseases, all of which are recognized as prominent comorbidities associated with congestive heart failure (CHF). However, it's important to note that the high saturation of generic drugs is expected to impede growth in the foreseeable future.

CHF remains a global concern, characterized by a high prevalence and significant morbidity and mortality rates. According to data from the Global Health Data Exchange registry, there were approximately 64.34 million cases of CHF worldwide, with around 5.5 million cases reported in the United States in 2022.

Currently, pharmaceutical options for CHF are evolving toward more effective treatments through product approvals and the introduction of new medications. For example, in February 2022, the FDA approved Boehringer Ingelheim's Jardiance (empagliflozin) for reducing the risk of cardiovascular death and hospitalization in adults. These new approvals and launches are driving market growth.

Furthermore, the surge in research and development activities and the presence of numerous drugs in the clinical pipeline create lucrative opportunities and intense competition among companies. For instance, in February 2022, the FDA accepted the New Drug Application (NDA) for Cytokinetics' drug Omecamtiv Mecarbil, a selective cardiac myosin activator shown to improve contractility in heart failure. The pipeline of CHF clinical trial drugs includes Furoscix infusor, CardiAMP cell therapy, Revascor (Rexlemestrocel-L), semaglutide, tirzepatide, cimlanod, and others. The approval and subsequent launch of such drugs in the coming years are expected to drive further growth.

Moreover, the increasing burden of diseases like diabetes and obesity contributes to the rising prevalence of CHF in the forecast period. For instance, research studies from the Centers for Disease Control and Prevention (CDC) demonstrate a strong link between CHF and diabetes, leading to an increased hospitalization rate in the United States. According to articles published by the National Center for Biotechnology Information (NCBI), approximately 35% of CHF patients also have diabetes mellitus.

During the pandemic, the clinical trial sector experienced setbacks, and the market witnessed disruptions in drug demand and supply, with patients facing challenges in accessing healthcare. Government and regulatory authorities-imposed restrictions that delayed clinical trial processes. However, after the first quarter of 2021, the market regained stability and resumed its regular pace.

The Global Heart Failure Therapeutics Market is segmented by drug class, distribution channel, region, and company.

Within its class, ACE inhibitors were the dominant force in the market in 2022. This can be attributed to its efficacy as a standalone treatment or its approved combinations available in the market. Additionally, it holds the top position as the preferred treatment option for patients suffering from congestive heart failure (CHF). This category encompasses medications such as Vasotec (enalapril), Zestril (lisinopril), Qbrelis (lisinopril), Prinivil (lisinopril), and captopril. These inhibitors function by blocking the production of Angiotensin-2, thereby reducing arterial pressure and increasing cardiac output, without affecting heart rate. This represents the most precisely targeted mechanism of action for managing heart failure.

Moreover, the expected approval of expanded labels for sodium-glucose co-transporter 2 (SGLT2) inhibitors specifically for CHF is anticipated to drive growth in this segment. For instance, in May 2020, Farxiga (dapigliflozin) and in February 2022, Jardiance (empagliflozin) received label extensions for the treatment of CHF. These SGLT2 inhibitors have demonstrated significant clinical benefits in protecting the heart and have shown a 35% reduction in hospitalization rates. Notably, this drug class has also demonstrated clinical efficacy in managing heart failure in patients without diabetes.

Based on distribution channel, hospital pharmacies claimed the largest market share in 2022. However, the retail pharmacy segment is expected to experience the most substantial growth in the foreseeable future. Retail pharmacies are well-suited for a wide range of medications, particularly in the context of homecare, given that the management of CHF often requires extended medication support. Moreover, CHF drugs are typically prescription medications, further bolstering the prospects of this segment.

Concurrently, the online pharmacy sector is projected to expand at a notable CAGR over the forecast period. Online pharmacy platforms offer the convenience of purchasing medications. Additionally, in emerging economies such as India, companies such as Netmeds Marketplace Ltd. and Tata 1mg actively promote online medicine procurement. Nevertheless, resistance to the online purchase of prescription drugs is expected to dampen growth in the online pharmacy segment.

 Major companies operating in Global Heart Failure Therapeutics Market are:

  • Bayer AG
  • Novartis AG
  • Merck & Co., Inc.
  • AstraZeneca PLC
  • Bristol-Myers Squibb Co
  • Amgen Inc
  • Boehringer Ingelheim GmbH
  • Pfizer Inc
  • Johnson & Johnson
  • Eli Lilly and Company

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“The global heart failure therapeutics market is on the cusp of exciting advancements. From precision medicine and novel drug classes to AI-powered diagnostics and gene therapies, the future holds promising developments that will improve outcomes for patients with heart failure. These trends reflect a commitment to delivering more effective, personalized, and accessible care, ultimately enhancing the prognosis and quality of life for individuals living with heart failure. As these trends continue to unfold, they will reshape the landscape of heart failure therapeutics for the better,” said Mr. Karan Chechi, Research Director with TechSci Research, a research-based management consulting firm.

Heart Failure Therapeutics Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Drug Class (ACE Inhibitors, Angiotensin 2 Receptor Blockers, Beta Blockers, Diuretics, Aldosterone Antagonists, Inotropes, Others), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies), By Region, and By Competition 2021-2031F”, has evaluated the future growth potential of Global Heart Failure Therapeutics Market and provides statistics & information on market size, structure and future market growth. The report aims to provide cutting-edge market intelligence and help decision-makers make sound investment decisions. Besides, the report also identifies and analyzes the emerging trends along with essential drivers, challenges, and opportunities in Global Heart Failure Therapeutics Market.

 

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Heart Failure Therapeutics Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Drug Class (ACE Inhibitors, Angiotensin 2 Receptor Blockers, Beta Blockers, Diuretics, Aldosterone Antagonists, Inotropes, Others), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies), By Region, and By Competition 2021-2031F

Healthcare | Dec, 2025

Increasing prevalence of heart failure, primarily driven by aging populations and rising incidences of chronic diseases like diabetes and hypertension are factors driving the Global Heart Failure Therapeutics market in the forecast period 2027-2031.

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